Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/143495
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dc.contributor.authorHtike, Thein Thanen_US
dc.contributor.authorMishra, Sachinen_US
dc.contributor.authorKumar, Sundramurthyen_US
dc.contributor.authorPadmanabhan, Parasuramanen_US
dc.contributor.authorGulyás, Balázsen_US
dc.date.accessioned2020-09-04T07:36:12Z-
dc.date.available2020-09-04T07:36:12Z-
dc.date.issued2018-
dc.identifier.citationHtike, T. T., Mishra, S., Kumar, S., Padmanabhan, P., & Gulyás, B. (2019). Peripheral biomarkers for early detection of Alzheimer’s and Parkinson’s diseases. Molecular Neurobiology, 56(3), 2256-2277. doi:10.1007/s12035-018-1151-4en_US
dc.identifier.issn0893-7648en_US
dc.identifier.urihttps://hdl.handle.net/10356/143495-
dc.description.abstractNeurological disorders are found to be influencing the peripheral tissues outside CNS. Recent developments in biomarkers for CNS have emerged with various diagnostic and therapeutic shortcomings. The role of central biomarkers including CSF-based and molecular imaging-based probes are still unclear for early diagnosis of major neurological diseases. Current trends show that early detection of neurodegenerative diseases with non-invasive methods is a major focus of researchers, and the development of biomarkers aiming peripheral tissues is in demand. Alzheimer's and Parkinson's diseases are known for the progressive loss in neural structures or functions, including the neural death. Various dysfunctions of metabolic and biochemical pathways are associated with early occurrence of neuro-disorders in peripheral tissues including skin, blood cells, and eyes. This article reviews the peripheral biomarkers explored for early detection of Alzheimer's and Parkinson's diseases including blood cells, skin fibroblast, proteomics, saliva, olfactory, stomach and colon, heart and peripheral nervous system, and others.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relation.ispartofMolecular Neurobiologyen_US
dc.rights© 2019 Springer Science+Business Media. This is a post-peer-review, pre-copyedit version of an article published in Molecular Neurobiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12035-018-1151-4en_US
dc.subjectScience::Medicineen_US
dc.titlePeripheral biomarkers for early detection of Alzheimer's and Parkinson's diseasesen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1007/s12035-018-1151-4-
dc.description.versionAccepted versionen_US
dc.identifier.pmid30008073-
dc.identifier.scopus2-s2.0-85049896983-
dc.identifier.issue3en_US
dc.identifier.volume56en_US
dc.identifier.spage2256en_US
dc.identifier.epage2277en_US
dc.subject.keywordsPeripheral Biomarkersen_US
dc.subject.keywordsAlzheimer’s Diseaseen_US
dc.description.acknowledgementThe authors (BG and PP) acknowledges The Lee Kong Chian School of Medicine, Nanyang Technological University MOE Start-Up Grant and MOE Tier-1 grants (2014-T1-001-229-1T1-04/14 and L0421160-1T1-06/15), Singapore.en_US
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Appears in Collections:LKCMedicine Journal Articles
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