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Title: AIE featured inorganic-organic Core@Shell nanoparticles for high-efficiency siRNA delivery and real-time monitoring
Authors: He, Xuewen
Yin, Feng
Wang, Dongyuan
Xiong, Ling-Hong
Kwok, Ryan T. K.
Gao, Peng Fei
Zhao, Zheng
Lam, Jacky W. Y.
Yong, Ken-Tye
Li, Zigang
Tang, Ben Zhong
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2019
Source: He, X., Yin, F., Wang, D., Xiong, L.-H., Kwok, R. T. K., Gao, P. F., . . . Tang, B. Z. (2019).AIE featured inorganic-organic Core@Shell nanoparticles for high-efficiency siRNA delivery and real-time monitoring. Nano Letters, 19(4), 2272-2279. doi:10.1021/acs.nanolett.8b04677
Journal: Nano Letters
Abstract: RNA interference (RNAi) is demonstrated as one of the most powerful technologies for sequence-specific suppression of genes in disease therapeutics. Exploration of novel vehicles for small interfering RNA (siRNA) delivery with high efficiency, low cytotoxicity, and self-monitoring functionality is persistently pursued. Herein, by taking advantage of aggregation-induced emission luminogen (AIEgen), we developed a novel class of Ag@AIE core@shell nanocarriers with regulable and uniform morphology. It presented excellent efficiencies in siRNA delivery, target gene knockdown, and cancer cell inhibition in vitro. What's more, an anticancer efficacy up to 75% was achieved in small animal experiments without obvious toxicity. Attributing to the unique AIE properties, real-time intracellular tracking of siRNA delivery and long-term tumor tissue imaging were successfully realized. Compared to the commercial transfection reagents, significant improvements were obtained in biocompatibility, delivery efficiency, and reproducibility, representing a promising future of this nanocarrier in RNAi-related cancer therapeutics.
ISSN: 1530-6984
DOI: 10.1021/acs.nanolett.8b04677
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
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