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Title: “Wax-sealed” theranostic nanoplatform for enhanced afterglow imaging-guided photothermally triggered photodynamic therapy
Authors: Liu, Gongyuan
Zhang, Shichao
Shi, Yunhao
Huang, Xiaoyu
Tang, Yunyun
Chen, Peng
Si, Weili
Huang, Wei
Dong, Xiaochen
Keywords: Engineering::Bioengineering
Issue Date: 2018
Source: Liu, G., Zhang, S., Shi, Y., Huang, X., Tang, Y., Chen, P., ... Dong, X. (2018). “Wax-sealed” theranostic nanoplatform for enhanced afterglow imaging-guided photothermally triggered photodynamic therapy. Advanced Functional Materials, 28(42), 1804317-. doi:10.1002/adfm.201804317
Journal: Advanced Functional Materials
Abstract: Herein, persistent luminescence nanoparticles (PLNPs) and photosensitizer are integrated for cancer theranostics with high specificity and without the need of continuous illumination. Specifically, ZnGa1.996O4:Cr0.004 (PLNPs) and IR780 (photosensitizer) are encapsulated by a temperature‐responsive “wax‐seal” composed of oleic acid and hexadecanol. The seal prevents luminescence quenching and premature initiation of photodynamic therapy (PDT), until it is melted down by heat stimulus. After photothermal activation, the near‐infrared afterglow offered by PLNPs provides imaging with high signal‐to‐background ratio because of the absence of tissue autofluorescence, as well as continuously excited photosensitizer for reactive oxygen species generation. Such theranostic nanoplatform offers multimodal imaging–guided localized cancer PDT.
ISSN: 1616-3028
DOI: 10.1002/adfm.201804317
Rights: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles


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