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Title: Rational design of a scalable bioprocess platform for bacterial cellulose production
Authors: Basu, Anindya
Vadanan, Sundaravadanam Vishnu
Lim, Sierin
Keywords: Engineering::Chemical engineering
Issue Date: 2018
Source: Basu, A., Vadanan, S. V., & Lim, S. (2019). Rational design of a scalable bioprocess platform for bacterial cellulose production. Carbohydrate Polymers, 207, 684-693. doi:10.1016/j.carbpol.2018.10.085
Project: NRF2013-THE001-046
Journal: Carbohydrate Polymers
Abstract: Bacterial cellulose (BC) has been gaining importance over the past decades as a versatile material that finds applications in diverse industries. However, a secured supply is hindered by the slow production rate and batch-to-batch variability of the yield. Here, we report a rational approach for characterising the BC production process using Design of Experiment (DoE) methodology to study the impact of different parameters on desired process attributes. Notably, we found that the carbon source used for bacterial growth significantly impacts the interplay between the process variables and affects the desired outcomes. We therefore, propose that the highest priority process outcome in this study, the yield, is a function of the carbon source and optimal reactor design. Our systematic approach has achieved projected BC yields as high as ∼40 g/L for Gluconacetobacter hansenii 53582 grown on sucrose as the carbon source compared to the widely reported yields of ∼10 g/L.
ISSN: 0144-8617
DOI: 10.1016/j.carbpol.2018.10.085
Rights: © 2018 Elsevier Ltd. All Rights Reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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