Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/143693
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dc.contributor.authorBasu, Anindyaen_US
dc.contributor.authorVadanan, Sundaravadanam Vishnuen_US
dc.contributor.authorLim, Sierinen_US
dc.date.accessioned2020-09-17T01:58:44Z-
dc.date.available2020-09-17T01:58:44Z-
dc.date.issued2018-
dc.identifier.citationBasu, A., Vadanan, S. V., & Lim, S. (2019). Rational design of a scalable bioprocess platform for bacterial cellulose production. Carbohydrate Polymers, 207, 684-693. doi:10.1016/j.carbpol.2018.10.085en_US
dc.identifier.issn0144-8617en_US
dc.identifier.urihttps://hdl.handle.net/10356/143693-
dc.description.abstractBacterial cellulose (BC) has been gaining importance over the past decades as a versatile material that finds applications in diverse industries. However, a secured supply is hindered by the slow production rate and batch-to-batch variability of the yield. Here, we report a rational approach for characterising the BC production process using Design of Experiment (DoE) methodology to study the impact of different parameters on desired process attributes. Notably, we found that the carbon source used for bacterial growth significantly impacts the interplay between the process variables and affects the desired outcomes. We therefore, propose that the highest priority process outcome in this study, the yield, is a function of the carbon source and optimal reactor design. Our systematic approach has achieved projected BC yields as high as ∼40 g/L for Gluconacetobacter hansenii 53582 grown on sucrose as the carbon source compared to the widely reported yields of ∼10 g/L.en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationNRF2013-THE001-046en_US
dc.relation.ispartofCarbohydrate Polymersen_US
dc.rights© 2018 Elsevier Ltd. All Rights Reserved.en_US
dc.subjectEngineering::Chemical engineeringen_US
dc.titleRational design of a scalable bioprocess platform for bacterial cellulose productionen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1016/j.carbpol.2018.10.085-
dc.identifier.pmid30600054-
dc.identifier.volume207en_US
dc.identifier.spage684en_US
dc.identifier.epage693en_US
dc.subject.keywordsBacterial Celluloseen_US
dc.subject.keywordsDesign of Experimentsen_US
dc.description.acknowledgementThis research was funded by the Singapore National Research Foundation (NRF) Biological Design, Tools, and Applications (BDTA) Grant (NRF2013-THE001-046).en_US
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item.grantfulltextnone-
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