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Title: A 'culture' shift : application of molecular techniques for diagnosing polymicrobial infections
Authors: Zhang, Yi
Hu, Anne
Andini, Nadya
Yang, Samuel
Keywords: Engineering::Mechanical engineering
Issue Date: 2019
Source: Zhang, Y., Hu, A., Andini, N., & Yang, S. (2019). A ‘culture’ shift: Application of molecular techniques for diagnosing polymicrobial infections. Biotechnology Advances, 37(3), 476–490. doi:10.1016/j.biotechadv.2019.02.013
Journal: Biotechnology advances
Abstract: With the advancement of microbiological discovery, it is evident that many infections, particularly bloodstream infections, are polymicrobial in nature. Consequently, new challenges have emerged in identifying the numerous etiologic organisms in an accurate and timely manner using the current diagnostic standard. Various molecular diagnostic methods have been utilized as an effort to provide a fast and reliable identification in lieu or parallel to the conventional culture-based methods. These technologies are mostly based on nucleic acid, proteins, or physical properties of the pathogens with differing advantages and limitations. This review evaluates the different molecular methods and technologies currently available to diagnose polymicrobial infections, which will help determine the most appropriate option for future diagnosis.
ISSN: 0734-9750
DOI: 10.1016/j.biotechadv.2019.02.013
Schools: School of Mechanical and Aerospace Engineering 
Rights: © 2019 Elsevier Inc. All rights reserved. This paper was published in Biotechnology advances and is made available with permission of Elsevier Inc.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles

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