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dc.contributor.authorWu, Junfangen_US
dc.contributor.authorZhu, Xuehangen_US
dc.contributor.authorLin, Hongen_US
dc.contributor.authorChen, Ziliangen_US
dc.contributor.authorTang, Huiruen_US
dc.contributor.authorWang, Yulanen_US
dc.identifier.citationWu, J., Zhu, X., Lin, H., Chen, Z., Tang, H., & Wang, Y. (2020). Gender differences in the bile acid profiles of APP/PS1 transgenic AD mice. Brain Research Bulletin, 161, 116–126. doi:10.1016/j.brainresbull.2020.05.003en_US
dc.description.abstractAlzheimer's disease (AD) is a neurodegenerative disease and presents in the accumulation of amyloid and neurofibrillary tangle. The association between modulations of gut symbiotic microbes with neurological disease via bidirectional gut-brain axis has been well documented. Bile acid (BA) pools in the enterohepatic circulation could be valuable for probing complex biochemical interactions between host and their symbiotic microbiota. Herein we investigated the levels of 28 BAs in several compartments in enterohepatic circulation (including jejunal, ileum, cecum, colon and feces, plasma and liver tissue) by employing an APP/PS1 induced transgenic AD mouse model. We found that BA profiles in AD mice were gender specific. We observed decreased levels of taurine-conjugated primary BAs (TUDCA, TCA, T-α-MCA and T-β-MCA) and increased levels of secondary BA (iso-DCA) in plasma and liver extracts for female AD transgenic mice. In contrast, increased levels of TDCA in liver extracts and decreased levels of T-β-MCA in jejunal content were noted in male AD mice. These observations suggested that perturbations of BA profiles in AD mice displayed clear gender variations. Our study highlighted the roles of gut microbiota on neurodegenerative disease, which could be gender specific.en_US
dc.relation.ispartofBrain research bulletinen_US
dc.rights© 2020 Elsevier Inc. All rights reserved. This paper was published in Brain research bulletin and is made available with permission of Elsevier Inc.en_US
dc.titleGender differences in the bile acid profiles of APP/PS1 transgenic AD miceen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.organizationSingapore Phenome Centeren_US
dc.description.versionAccepted versionen_US
dc.subject.keywordsBile Aciden_US
dc.subject.keywordsGender Differenceen_US
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