Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/143873
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dc.contributor.authorLoh, Marieen_US
dc.contributor.authorZhou, Lien_US
dc.contributor.authorNg, Hong Kiaten_US
dc.contributor.authorChambers, John Campbellen_US
dc.date.accessioned2020-09-29T02:19:03Z-
dc.date.available2020-09-29T02:19:03Z-
dc.date.issued2019-
dc.identifier.citationLoh, M., Zhou, L., Ng, H. K., & Chambers, J. C. (2019). Epigenetic disturbances in obesity and diabetes : epidemiological and functional insights. Molecular Metabolism, 27, S33-S41. doi:10.1016/j.molmet.2019.06.011en_US
dc.identifier.issn2212-8778en_US
dc.identifier.urihttps://hdl.handle.net/10356/143873-
dc.description.abstractBackground: Obesity and type 2 diabetes (T2D) are major public health issues worldwide, and put a significant burden on the healthcare system. Genetic variants, along with traditional risk factors such as diet and physical activity, could account for up to approximately a quarter of disease risk. Epigenetic factors have demonstrated potential in accounting for additional phenotypic variation, along with providing insights into the causal relationship linking genetic variants to phenotypes. Scope of review: In this review article, we discuss the epidemiological and functional insights into epigenetic disturbances in obesity and diabetes, along with future research directions and approaches, with a focus on DNA methylation. Major conclusions: Epigenetic mechanisms have been shown to contribute to obesity and T2D disease development, as well as potential differences in disease risks between ethnic populations. Technology to investigate epigenetic profiles in diseased individuals and tissues has advanced significantly in the last years, and suggests potential in application of epigenetic factors in clinical monitoring and as therapeutic options.en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.language.isoenen_US
dc.relation.ispartofMolecular Metabolismen_US
dc.rights© 2019 Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.subjectScience::Medicineen_US
dc.titleEpigenetic disturbances in obesity and diabetes : epidemiological and functional insightsen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.organizationTranslational Laboratory in Genetic Medicine, A*STARen_US
dc.identifier.doi10.1016/j.molmet.2019.06.011-
dc.description.versionPublished versionen_US
dc.identifier.pmid31500829-
dc.identifier.volume27en_US
dc.identifier.spageS33en_US
dc.identifier.epageS41en_US
dc.subject.keywordsEpigeneticsen_US
dc.subject.keywordsDNA Methylationen_US
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item.grantfulltextopen-
Appears in Collections:LKCMedicine Journal Articles
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