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Title: Ligase-controlled cyclo-oligomerization of peptides
Authors: Hemu, Xinya
Zhang, Xiaohong
Tam, James P.
Keywords: Science::Biological sciences
Issue Date: 2019
Source: Hemu, X., Zhang, X., & Tam, J. P. (2019). Ligase-Controlled Cyclo-oligomerization of Peptides. Organic Letters, 21(7), 2029–2032. doi:10.1021/acs.orglett.9b00151
Journal: Organic letters
Abstract: A biomimetic one-step ligase-catalyzed cyclo-oligomerization mediated by butelase 1, an Asn/Asp-specific ligase, is introduced that is time-, concentration-, length-, and sequence-dependent. This reaction yields cyclic mono-, di-, tri-, and tetramers from peptide precursors containing 3-15 amino acids ended with Asn and a His-Val tail. The cyclomonomers were favored when the peptide lengths were >9 amino acids. A turn-forming Pro residue at the P2 position favored the formation of higher-order cyclo-oligomers.
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.9b00151
Schools: School of Biological Sciences 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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