Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/143886
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHemu, Xinyaen_US
dc.contributor.authorZhang, Xiaohongen_US
dc.contributor.authorTam, James P.en_US
dc.date.accessioned2020-09-29T07:47:55Z-
dc.date.available2020-09-29T07:47:55Z-
dc.date.issued2019-
dc.identifier.citationHemu, X., Zhang, X., & Tam, J. P. (2019). Ligase-Controlled Cyclo-oligomerization of Peptides. Organic Letters, 21(7), 2029–2032. doi:10.1021/acs.orglett.9b00151en_US
dc.identifier.issn1523-7060en_US
dc.identifier.urihttps://hdl.handle.net/10356/143886-
dc.description.abstractA biomimetic one-step ligase-catalyzed cyclo-oligomerization mediated by butelase 1, an Asn/Asp-specific ligase, is introduced that is time-, concentration-, length-, and sequence-dependent. This reaction yields cyclic mono-, di-, tri-, and tetramers from peptide precursors containing 3-15 amino acids ended with Asn and a His-Val tail. The cyclomonomers were favored when the peptide lengths were >9 amino acids. A turn-forming Pro residue at the P2 position favored the formation of higher-order cyclo-oligomers.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relation.ispartofOrganic lettersen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.9b00151en_US
dc.subjectScience::Biological sciencesen_US
dc.titleLigase-controlled cyclo-oligomerization of peptidesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doi10.1021/acs.orglett.9b00151-
dc.description.versionAccepted versionen_US
dc.identifier.pmid30763108-
dc.identifier.issue7en_US
dc.identifier.volume21en_US
dc.identifier.spage2029en_US
dc.identifier.epage2032en_US
dc.subject.keywordsPeptides And Proteinsen_US
dc.subject.keywordsBacteriaen_US
dc.description.acknowledgementWe thank National University Hospital of Singapore for providing the drug-resistant bacteria strains for the research purpose. This research was supported by Academic Research Grant Tier 3 (MOE2016-T3-1-003) from Singapore Minister of Education (MOE).en_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:SBS Journal Articles
Files in This Item:
File Description SizeFormat 
Ligase Controlled Cyclo-oligomerization of Peptides.pdf585.98 kBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations 20

10
Updated on Mar 28, 2023

Web of ScienceTM
Citations 20

11
Updated on Mar 31, 2023

Page view(s)

161
Updated on Apr 1, 2023

Download(s) 50

129
Updated on Apr 1, 2023

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.