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https://hdl.handle.net/10356/143886
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DC Field | Value | Language |
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dc.contributor.author | Hemu, Xinya | en_US |
dc.contributor.author | Zhang, Xiaohong | en_US |
dc.contributor.author | Tam, James P. | en_US |
dc.date.accessioned | 2020-09-29T07:47:55Z | - |
dc.date.available | 2020-09-29T07:47:55Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Hemu, X., Zhang, X., & Tam, J. P. (2019). Ligase-Controlled Cyclo-oligomerization of Peptides. Organic Letters, 21(7), 2029–2032. doi:10.1021/acs.orglett.9b00151 | en_US |
dc.identifier.issn | 1523-7060 | en_US |
dc.identifier.uri | https://hdl.handle.net/10356/143886 | - |
dc.description.abstract | A biomimetic one-step ligase-catalyzed cyclo-oligomerization mediated by butelase 1, an Asn/Asp-specific ligase, is introduced that is time-, concentration-, length-, and sequence-dependent. This reaction yields cyclic mono-, di-, tri-, and tetramers from peptide precursors containing 3-15 amino acids ended with Asn and a His-Val tail. The cyclomonomers were favored when the peptide lengths were >9 amino acids. A turn-forming Pro residue at the P2 position favored the formation of higher-order cyclo-oligomers. | en_US |
dc.description.sponsorship | Ministry of Education (MOE) | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Organic letters | en_US |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.9b00151 | en_US |
dc.subject | Science::Biological sciences | en_US |
dc.title | Ligase-controlled cyclo-oligomerization of peptides | en_US |
dc.type | Journal Article | en |
dc.contributor.school | School of Biological Sciences | en_US |
dc.identifier.doi | 10.1021/acs.orglett.9b00151 | - |
dc.description.version | Accepted version | en_US |
dc.identifier.pmid | 30763108 | - |
dc.identifier.issue | 7 | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.spage | 2029 | en_US |
dc.identifier.epage | 2032 | en_US |
dc.subject.keywords | Peptides And Proteins | en_US |
dc.subject.keywords | Bacteria | en_US |
dc.description.acknowledgement | We thank National University Hospital of Singapore for providing the drug-resistant bacteria strains for the research purpose. This research was supported by Academic Research Grant Tier 3 (MOE2016-T3-1-003) from Singapore Minister of Education (MOE). | en_US |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
Appears in Collections: | SBS Journal Articles |
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File | Description | Size | Format | |
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Ligase Controlled Cyclo-oligomerization of Peptides.pdf | 585.98 kB | Adobe PDF | ![]() View/Open |
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