Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/143886
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dc.contributor.authorHemu, Xinyaen_US
dc.contributor.authorZhang, Xiaohongen_US
dc.contributor.authorTam, James P.en_US
dc.date.accessioned2020-09-29T07:47:55Z-
dc.date.available2020-09-29T07:47:55Z-
dc.date.issued2019-
dc.identifier.citationHemu, X., Zhang, X., & Tam, J. P. (2019). Ligase-Controlled Cyclo-oligomerization of Peptides. Organic Letters, 21(7), 2029–2032. doi:10.1021/acs.orglett.9b00151en_US
dc.identifier.issn1523-7060en_US
dc.identifier.urihttps://hdl.handle.net/10356/143886-
dc.description.abstractA biomimetic one-step ligase-catalyzed cyclo-oligomerization mediated by butelase 1, an Asn/Asp-specific ligase, is introduced that is time-, concentration-, length-, and sequence-dependent. This reaction yields cyclic mono-, di-, tri-, and tetramers from peptide precursors containing 3-15 amino acids ended with Asn and a His-Val tail. The cyclomonomers were favored when the peptide lengths were >9 amino acids. A turn-forming Pro residue at the P2 position favored the formation of higher-order cyclo-oligomers.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relation.ispartofOrganic lettersen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.9b00151en_US
dc.subjectScience::Biological sciencesen_US
dc.titleLigase-controlled cyclo-oligomerization of peptidesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doi10.1021/acs.orglett.9b00151-
dc.description.versionAccepted versionen_US
dc.identifier.pmid30763108-
dc.identifier.issue7en_US
dc.identifier.volume21en_US
dc.identifier.spage2029en_US
dc.identifier.epage2032en_US
dc.subject.keywordsPeptides And Proteinsen_US
dc.subject.keywordsBacteriaen_US
dc.description.acknowledgementWe thank National University Hospital of Singapore for providing the drug-resistant bacteria strains for the research purpose. This research was supported by Academic Research Grant Tier 3 (MOE2016-T3-1-003) from Singapore Minister of Education (MOE).en_US
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