Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/143886
Title: | Ligase-controlled cyclo-oligomerization of peptides | Authors: | Hemu, Xinya Zhang, Xiaohong Tam, James P. |
Keywords: | Science::Biological sciences | Issue Date: | 2019 | Source: | Hemu, X., Zhang, X., & Tam, J. P. (2019). Ligase-Controlled Cyclo-oligomerization of Peptides. Organic Letters, 21(7), 2029–2032. doi:10.1021/acs.orglett.9b00151 | Journal: | Organic letters | Abstract: | A biomimetic one-step ligase-catalyzed cyclo-oligomerization mediated by butelase 1, an Asn/Asp-specific ligase, is introduced that is time-, concentration-, length-, and sequence-dependent. This reaction yields cyclic mono-, di-, tri-, and tetramers from peptide precursors containing 3-15 amino acids ended with Asn and a His-Val tail. The cyclomonomers were favored when the peptide lengths were >9 amino acids. A turn-forming Pro residue at the P2 position favored the formation of higher-order cyclo-oligomers. | URI: | https://hdl.handle.net/10356/143886 | ISSN: | 1523-7060 | DOI: | 10.1021/acs.orglett.9b00151 | Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.9b00151 | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Journal Articles |
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Ligase Controlled Cyclo-oligomerization of Peptides.pdf | 585.98 kB | Adobe PDF | ![]() View/Open |
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