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Title: Application of computational biology and artificial intelligence technologies in cancer precision drug discovery
Authors: Nagarajan, Nagasundaram
Yapp, Edward K. Y.
Le, Nguyen Quoc Khanh
Kamaraj, Balu
Abeer Mohammed Al-Subaie
Yeh, Hui-Yuan
Keywords: Humanities::General
Issue Date: 2019
Source: Nagarajan, N., Yapp, E. K. Y., Le, N. Q. K., Kamaraj, B., Abeer Mohammed Al-Subaie, & Yeh, H.-Y. (2019). Application of computational biology and artificial intelligence technologies in cancer precision drug discovery. BioMed Research International, 2019, 1-15. doi:10.1155/2019/8427042
Journal: BioMed Research International
Abstract: Artificial intelligence (AI) proves to have enormous potential in many areas of healthcare including research and chemical discoveries. Using large amounts of aggregated data, the AI can discover and learn further transforming these data into "usable" knowledge. Being well aware of this, the world's leading pharmaceutical companies have already begun to use artificial intelligence to improve their research regarding new drugs. The goal is to exploit modern computational biology and machine learning systems to predict the molecular behaviour and the likelihood of getting a useful drug, thus saving time and money on unnecessary tests. Clinical studies, electronic medical records, high-resolution medical images, and genomic profiles can be used as resources to aid drug development. Pharmaceutical and medical researchers have extensive data sets that can be analyzed by strong AI systems. This review focused on how computational biology and artificial intelligence technologies can be implemented by integrating the knowledge of cancer drugs, drug resistance, next-generation sequencing, genetic variants, and structural biology in the cancer precision drug discovery.
ISSN: 2314-6133
DOI: 10.1155/2019/8427042
Rights: © 2019 Nagasundaram Nagarajan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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