Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/144027
Title: Organic photodynamic nanoinhibitor for synergistic cancer therapy
Authors: Jiang, Yuyan
Li, Jingchao
Zeng, Ziling
Xie, Chen
Lyu, Yan
Pu, Kanyi
Keywords: Engineering::Chemical engineering
Issue Date: 2019
Source: Jiang, Y., Li, J., Zeng, Z., Xie, C., Lyu, Y., & Pu, K. (2019). Organic photodynamic nanoinhibitor for synergistic cancer therapy. Angewandte Chemie International Edition, 58(24), 8161-8165. doi:10.1002/anie.201903968
Journal: Angewandte Chemie International Edition
Abstract: Despite its great potential in cancer treatment, photodynamic therapy (PDT) often exacerbates hypoxia and subsequently compromises its therapeutic efficacy. To overcome this issue, an organic photodynamic nanoinhibitor (OPNi) has been synthesized that has the additional ability to counteract carbonic anhydrase IX (CA‐IX), a molecular target in the hypoxia‐mediated signalling cascade. OPNi is composed of a metabolizable semiconducting polymer as the photosensitizer and a CA‐IX antagonist conjugated amphiphilic polymer as the matrix. This molecular structure allows OPNi not only to selectively bind CA‐IX positive cancer cells to facilitate its tumor accumulation but also to regulate the CA‐IX‐related pathway. The integration of CA‐IX inhibition into the targeted PDT process eventually has a synergistic effect, leading to superior antitumor efficacy over that of PDT alone, as well as the reduced probability of hypoxia‐induced cancer metastasis. This study thus proposes a molecular strategy to devise simple yet amplified photosensitizers to conquer the pitfalls of traditional PDT.
URI: https://hdl.handle.net/10356/144027
ISSN: 1433-7851
DOI: 10.1002/anie.201903968
Rights: This is the accepted version of the following article: Jiang, Y., Li, J., Zeng, Z., Xie, C., Lyu, Y., & Pu, K. (2019). Organic photodynamic Nanoinhibitor for synergistic cancer therapy. Angewandte Chemie International Edition, 58(24), 8161-8165. doi:10.1002/anie.201903968, which has been published in final form at http://doi.org/10.1002/anie.201903968. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

Files in This Item:
File Description SizeFormat 
Organic Photodynamic Nanoinhibitor for Synergistic Cancer Therapy.pdf2.16 MBAdobe PDFView/Open

SCOPUSTM   
Citations 5

83
Updated on Mar 2, 2021

PublonsTM
Citations 5

68
Updated on Mar 3, 2021

Page view(s)

67
Updated on Sep 21, 2021

Download(s) 50

21
Updated on Sep 21, 2021

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.