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Title: Standardizing Monte Carlo simulation parameters for a reproducible dose-averaged linear energy transfer
Authors: Koh, Calvin Wei Yang
Tan, Hong Qi
Ang, Khong Wei
Park, Sung Yong
Lew, Wen Siang
Lee, James Cheow Lei
Keywords: Science
Issue Date: 2020
Source: Koh, C. W. Y., Tan, H. Q., Ang, K. W., Park, S. Y., Lew, W. S., & Lee, J. C. L. (2020). Standardizing Monte Carlo simulation parameters for a reproducible dose-averaged linear energy transfer. British Journal of Radiology, 93(1112), 1-11. doi:10.1259/bjr.20200122
Journal: British Journal of Radiology
Abstract: Objective: Dose-averaged linear energy transfer (LETD) is one of the factors which determines relative biological effectiveness (RBE) for treatment planning in proton therapy. It is usually determined from Monte Carlo (MC) simulation. However, no standard simulation protocols were established for sampling of LETD. Simulation parameters like maximum step length and range cut will affect secondary electrons production and have an impact on the accuracy of dose distribution and LETD. We aim to show how different combinations of step length and range cut in GEANT4 will affect the result in sampling of LETD using different MC scoring methods. Methods: In this work, different step length and range cut value in a clinically relevant voxel geometry were used for comparison. Different LETD scoring methods were established and the concept of covariance between energy deposition per step and step length is used to explain the differences between them. Results: We recommend a maximum step length of 0.05 mm and a range cut of 0.01 mm in MC simulation as this yields the most consistent LETD value across different scoring methods. Different LETD scoring methods are also compared and variation up to 200% can be observed at the plateau of 80 MeV proton beam. Scoring Method one has one of the lowest percentage differences compared across all simulation parameters. Conclusion: We have determined a set of maximum step length and range cut parameters to be used for LETD scoring in a 1 mm voxelized geometry. LETD scoring method should also be clearly defined and standardized to facilitate cross-institutional studies. Advances in knowledge: Establishing a standard simulation protocol for sampling LETD would reduce the discrepancy when comparing data across different centres, and this can improve the calculation for RBE.
ISSN: 0007-1285
DOI: 10.1259/bjr.20200122
Rights: © 2020 The Authors (Published by the British Institute of Radiology). All rights reserved. This paper was published in British Journal of Radiology and is made available with permission of The Authors (Published by the British Institute of Radiology).
Fulltext Permission: open
Fulltext Availability: With Fulltext
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