Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/144128
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dc.contributor.authorNair, Radhika V.en_US
dc.contributor.authorYi, Pae Jianen_US
dc.contributor.authorPadmanabhan, Parasuramanen_US
dc.contributor.authorGulyás, Balázsen_US
dc.contributor.authorMurukeshan, V. M.en_US
dc.date.accessioned2020-10-14T08:10:29Z-
dc.date.available2020-10-14T08:10:29Z-
dc.date.issued2020-
dc.identifier.citationNair, R. V., Yi, P. J., Padmanabhan, P., Gulyás, B., & Murukeshan, V. M. (2020). Au nano-urchins enabled localized surface plasmon resonance sensing of beta amyloid fibrillation. Nanoscale Advances, 2(7), 2693-2698. doi:10.1039/D0NA00164Cen_US
dc.identifier.issn2516-0230en_US
dc.identifier.urihttps://hdl.handle.net/10356/144128-
dc.description.abstractEarly stage detection of neurodegenerative diseases such as Alzheimer's disease (AD) is of utmost importance, as it has become one of the leading causes of death of millions of people. The gradual intellectual decline in AD patients is an outcome of fibrillation of amyloid beta 1–42 (Aβ1–42) peptides in the brain. In this paper, we present localized surface plasmon resonance (LSPR) based sensing of Aβ1–42 fibrillation using Au nano-urchins. Strongly localized field confinement at the spiky nanostructures of nano-urchin surfaces enables them to detect very low concentrations of Aβ1–42. In addition, the LSPR peak of Au nano-urchins, which is very sensitive to ambient conditions, shows significant responses at different fibrillation stages of Aβ1–42. Reduction in LSPR peak intensity with an increase in the fibrillation is chosen as the sensing parameter here. This paper in this context provides LSPR based highly sensitive, label-free and real-time sensing of Aβ1–42 fibrillation that is highly advantageous compared to the existing techniques which require binding additives or fluorescent biomarkers.en_US
dc.description.sponsorshipEconomic Development Board (EDB)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relationRG 192/17en_US
dc.relation.ispartofNanoscale Advancesen_US
dc.rights© 2020 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.en_US
dc.subjectScienceen_US
dc.titleAu nano-urchins enabled localized surface plasmon resonance sensing of beta amyloid fibrillationen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.1039/D0NA00164C-
dc.description.versionPublished versionen_US
dc.identifier.issue7en_US
dc.identifier.volume2en_US
dc.identifier.spage2693en_US
dc.identifier.epage2698en_US
dc.subject.keywordsAmyloidsen_US
dc.subject.keywordsSurface Plasmon Resonanceen_US
dc.description.acknowledgementThe authors acknowledge NTU, COLE-EDB, and Ministry of Education, MoE Singapore (RG 192/17) for financial support.en_US
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