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|Title:||Understanding missing proteins : a functional perspective||Authors:||Zhou, Longjian
Goh, Wilson Wen Bin
|Keywords:||Science::Biological sciences||Issue Date:||2018||Source:||Zhou, L., Wong, L., & Goh, W. W. B. (2018). Understanding missing proteins : a functional perspective. Drug Discovery Today, 23(3), 644-651. doi:10.1016/j.drudis.2017.11.011||Journal:||Drug Discovery Today||Abstract:||A missing protein (MP) is an unconfirmed genetic sequence for which a protein product is not yet detected. Currently, MPs are tiered based on supporting evidence mainly in the form of protein existence (PE) classification. As we discuss here, this definition is overly restrictive because proteins go missing in day-to-day proteomics as a result of low abundance, lack of sequence specificity, splice variants, and so on. Thus, we propose a broader functional classification of MPs that complements PE classification, discuss major causes, and examine three corresponding solution tiers: biological, technical, and informatics. We assert that informatics-driven solutions would have a major role in resolving the MP problem (MPP).||URI:||https://hdl.handle.net/10356/144226||ISSN:||1878-5832||DOI:||10.1016/j.drudis.2017.11.011||Rights:||© 2017 Elsevier Ltd. All rights reserved.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SBS Journal Articles|
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