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Title: Understanding missing proteins : a functional perspective
Authors: Zhou, Longjian
Wong, Limsoon
Goh, Wilson Wen Bin
Keywords: Science::Biological sciences
Issue Date: 2018
Source: Zhou, L., Wong, L., & Goh, W. W. B. (2018). Understanding missing proteins : a functional perspective. Drug Discovery Today, 23(3), 644-651. doi:10.1016/j.drudis.2017.11.011
Journal: Drug Discovery Today 
Abstract: A missing protein (MP) is an unconfirmed genetic sequence for which a protein product is not yet detected. Currently, MPs are tiered based on supporting evidence mainly in the form of protein existence (PE) classification. As we discuss here, this definition is overly restrictive because proteins go missing in day-to-day proteomics as a result of low abundance, lack of sequence specificity, splice variants, and so on. Thus, we propose a broader functional classification of MPs that complements PE classification, discuss major causes, and examine three corresponding solution tiers: biological, technical, and informatics. We assert that informatics-driven solutions would have a major role in resolving the MP problem (MPP).
ISSN: 1878-5832
DOI: 10.1016/j.drudis.2017.11.011
Rights: © 2017 Elsevier Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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