Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/144239
Title: Unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein KR2
Authors: Mizutani, Yasuhisa
Keywords: Science::Chemistry
Issue Date: 2020
Source: Mizutani, Y. (2020). Unique structure of the retinal chromophore enabling sodium ion transport in the sodium ion-pumping protein KR2. Proc. Of the 7th Asian Spectroscopy Conference (ASC 2020). doi:10.32655/ASC_8-10_Dec2020.22
Abstract: Active ion transport across membranes is vital to maintaining the electrochemical gradients of ions in cells and is mediated by transmembrane proteins. Photoexcitation of some microbial rhodopsins leads to ion transport across membranes. They contain all-trans-retinal as a chromophore, which is covalently bound to a lysine residue through a protonated Schiff base linkage and surrounded by seven transmembrane α helices. Absorption of a photon results in the chromophore isomerization and leads to a cyclic reaction. To reveal mechanism in ion pumping, it is essential to elucidate sequential changes in the chromophore structure in a photocycle. Resonance Raman spectroscopy enables us to examine the evolution of the structural changes of the retinal chromophore and the protein moiety.[1-7]
URI: https://hdl.handle.net/10356/144239
DOI: 10.32655/ASC_8-10_Dec2020.22
Rights: © 2020 Nanyang Technological University.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:Asian Spectroscopy Conference

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