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Title: CaproGlu : multifunctional tissue adhesive platform
Authors: Djordjevic, Ivan
Pokholenko, Oleksandr
Shah, Ankur Harish
Wicaksono, Gautama
Blancafort, Lluis
Hanna, John V.
Page, Samuel J.
Nanda, Himansu Sekhar
Ong, Chee Bing
Chung, Sze Ryn
Chin, Andrew Yuan Hui
McGrouther, Duncan
Choudhury, Muntasir Mannan
Li, Fang
Teo, Jonathan Shunming
Lee, Lui Shiong
Steele, Terry W. J.
Keywords: Engineering::Materials::Biomaterials
Issue Date: 2020
Source: Djordjevic, I., Pokholenko, O., Shah, A. H., Wicaksono, G., Blancafort, L., Hanna, J. V., . . . Steele, T. W. J. (2020). CaproGlu: Multifunctional tissue adhesive platform. Biomaterials, 260, 120215-. doi:10.1016/j.biomaterials.2020.120215
Journal: Biomaterials
Abstract: Driven by the clinical need for a strong tissue adhesive with elastomeric material properties, a departure from legacy crosslinking chemistries was sought as a multipurpose platform for tissue mending. A fresh approach to bonding wet substrates has yielded a synthetic biomaterial that overcomes the drawbacks of free-radical and nature-inspired bioadhesives. A food-grade liquid polycaprolactone grafted with carbene precursors yields CaproGlu. The first-of-its-kind low-viscosity prepolymer is VOC-free and requires no photoinitiators. Grafted diazirine end-groups form carbene diradicals upon low energy UVA (365 nm) activation that immediately crosslink tissue surfaces; no pre-heating or animal-derived components are required. The hydrophobic polymeric environment enables metastable functional groups not possible in formulations requiring solvents or water. Activated diazirine within CaproGlu is uniquely capable of crosslinking all amino acids, even on wet tissue substrates. CaproGlu undergoes rapid liquid-to-biorubber transition within seconds of UVA exposure–features not found in any other bioadhesive. The exceptional shelf stability of CaproGlu allows gamma sterilization with no change in material properties. CaproGlu wet adhesiveness is challenged against current unmet clinical needs: anastomosis of spliced blood vessels, anesthetic muscle patches, and human platelet-mediating coatings. The versatility of CaproGlu enables both organic and inorganic composites for future bioadhesive platforms.
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2020.120215
Rights: © 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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