Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/144312
Title: Graphene quantum dot based charge-reversal nanomaterial for nucleus-targeted drug delivery and efficiency controllable photodynamic therapy
Authors: Ju, Jian
Regmi, Sagar
Fu, Afu
Lim, Sierin
Liu, Quan
Keywords: Engineering::Chemical engineering
Issue Date: 2019
Source: Ju, J., Regmi, S., Fu, A., Lim, S., & Liu, Q. (2019). Graphene quantum dot based charge-reversal nanomaterial for nucleus-targeted drug delivery and efficiency controllable photodynamic therapy. Journal of Biophotonics, 12(6), e201800367-. doi:10.1002/jbio.201800367
Journal: Journal of Biophotonics
Abstract: Graphene quantum dots (GQDs), the new zero‐dimensional carbon nanomaterial, have been demonstrated as a promising material for biomedical applications due to its good biocompatibility and low toxicity. However, the integration of multiple therapeutic approaches into a nanosized platform based on the GQD has not been explored yet to our best knowledge. In this report, we regulate the generation of reactive oxygen species (ROS) when using the GQD as a photosensitizer by varying the doping amount of nitrogen atoms to achieve efficiency controllable photodynamic therapy. On the other hand, charge‐reversal (3‐Aminopropyl) triethoxysilane (APTES) was used to conjugate on the surface of GQD for nucleus targeting drug delivery for the first time. The treatment outcome of produced ROS and nucleus‐targeting drug delivery was investigated by fluorescence imaging. The results demonstrated that the N‐GQD‐DOX‐APTES in dual roles as a drug carrier and photosensitizer could achieve nucleus‐targeting delivery and strong ROS production simultaneously. This approach provides a promising strategy for the development of multifunctional therapy in one nano platform for biomedical applications.
URI: https://hdl.handle.net/10356/144312
ISSN: 1864-063X
DOI: 10.1002/jbio.201800367
Rights: This is the accepted version of the following article: Ju, J., Regmi, S., Fu, A., Lim, S., & Liu, Q. (2019). Graphene quantum dot based charge-reversal nanomaterial for nucleus-targeted drug delivery and efficiency controllable photodynamic therapy. Journal of Biophotonics, 12(6), 201800367-. doi:10.1002/jbio.201800367, which has been published in final form at 10.1002/jbio.201800367. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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