Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/144312
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dc.contributor.authorJu, Jianen_US
dc.contributor.authorRegmi, Sagaren_US
dc.contributor.authorFu, Afuen_US
dc.contributor.authorLim, Sierinen_US
dc.contributor.authorLiu, Quanen_US
dc.date.accessioned2020-10-28T02:52:06Z-
dc.date.available2020-10-28T02:52:06Z-
dc.date.issued2019-
dc.identifier.citationJu, J., Regmi, S., Fu, A., Lim, S., & Liu, Q. (2019). Graphene quantum dot based charge-reversal nanomaterial for nucleus-targeted drug delivery and efficiency controllable photodynamic therapy. Journal of Biophotonics, 12(6), e201800367-. doi:10.1002/jbio.201800367en_US
dc.identifier.issn1864-063Xen_US
dc.identifier.urihttps://hdl.handle.net/10356/144312-
dc.description.abstractGraphene quantum dots (GQDs), the new zero‐dimensional carbon nanomaterial, have been demonstrated as a promising material for biomedical applications due to its good biocompatibility and low toxicity. However, the integration of multiple therapeutic approaches into a nanosized platform based on the GQD has not been explored yet to our best knowledge. In this report, we regulate the generation of reactive oxygen species (ROS) when using the GQD as a photosensitizer by varying the doping amount of nitrogen atoms to achieve efficiency controllable photodynamic therapy. On the other hand, charge‐reversal (3‐Aminopropyl) triethoxysilane (APTES) was used to conjugate on the surface of GQD for nucleus targeting drug delivery for the first time. The treatment outcome of produced ROS and nucleus‐targeting drug delivery was investigated by fluorescence imaging. The results demonstrated that the N‐GQD‐DOX‐APTES in dual roles as a drug carrier and photosensitizer could achieve nucleus‐targeting delivery and strong ROS production simultaneously. This approach provides a promising strategy for the development of multifunctional therapy in one nano platform for biomedical applications.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Biophotonicsen_US
dc.rightsThis is the accepted version of the following article: Ju, J., Regmi, S., Fu, A., Lim, S., & Liu, Q. (2019). Graphene quantum dot based charge-reversal nanomaterial for nucleus-targeted drug delivery and efficiency controllable photodynamic therapy. Journal of Biophotonics, 12(6), 201800367-. doi:10.1002/jbio.201800367, which has been published in final form at 10.1002/jbio.201800367. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].en_US
dc.subjectEngineering::Chemical engineeringen_US
dc.titleGraphene quantum dot based charge-reversal nanomaterial for nucleus-targeted drug delivery and efficiency controllable photodynamic therapyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1002/jbio.201800367-
dc.description.versionAccepted versionen_US
dc.identifier.pmid30701677-
dc.identifier.issue6en_US
dc.identifier.volume12en_US
dc.identifier.spagee201800367en_US
dc.subject.keywordsCharge-reversalen_US
dc.subject.keywordsGraphene Quantum Dotsen_US
dc.description.acknowledgementThe authors would like to acknowledge financial support from Tier 2 grants (No. MOE2015-T2-2-112 and MOE2017-T2-2-057) funded by the Ministry of Education in Singapore, NTU-AIT-MUV Programme in Advanced Biomedical Imaging (No. NAM/15004) funded by Nanyang Technological University (NTU), Industry Alignment Fund (Pre-Positioning) (Grant No. H17/01/a0/008 and H1 7/01/ a0/0F9) supported by Biomedical Research Council, Singapore.en_US
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