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Title: Photocurable platelet rich plasma bioadhesives
Authors: Singh, Manisha
Nanda, Himansu Sekhar
Lee, Justin Yin Hao
Wang, Jun Kit
Tan, Nguan Soon
Steele, Terry W. J.
Keywords: Engineering::Materials
Issue Date: 2020
Source: Singh, M., Nanda, H. S., Lee, J. Y. H., Wang, J. K., Tan, N. S., & Steele, T. W. J. (2020). Photocurable platelet rich plasma bioadhesives. Acta Biomaterialia, 117, 133-141. doi:10.1016/j.actbio.2020.09.030
Journal: Acta Biomaterialia
Abstract: Closure of wounds with tissue adhesives has many advantages over sutures, but existing synthetic adhesives are toxic and have poor workability. Blood-derived adhesives display complete resorption but have adhesion too weak for reliable wound dressings. We propose a semi-synthetic design that combines the positive attributes of synthetic and blood-derived tissue adhesives. PAMAM-g-diazirine (PDz) is a rapidly gelling bioadhesive miscible in both aqueous and organic solvents. PDz blended with platelet-rich plasma (PRP) forms PDz/PRP composite, a semi-synthetic formulation that combines PDz’s wet tissue adhesion with PRP’s potent wound healing properties. Light-activated PDz/PRP bioadhesive composite has similar elasticity to soft tissues and behaves as an induced hemostat—an unmet clinical need for rapid wound dressings. PDz/PRP composite applied to in vivo full-thickness wounds observed a 25% reduction in inflammation, as assessed by the host-cell response.
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2020.09.030
Rights: © 2020 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. All rights reserved. This paper was published in Acta Biomaterialia and is made available with permission of Elsevier Ltd. on behalf of Acta Materialia Inc.
Fulltext Permission: embargo_20221130
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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