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dc.contributor.authorSee, Yi Xiangen_US
dc.contributor.authorWang, Benny Zhengjieen_US
dc.contributor.authorFullwood, Melissa Janeen_US
dc.identifier.citationSee, Y. X., Wang, B. Z., & Fullwood, M. J. (2019). Chromatin interactions and regulatory elements in cancer : from bench to bedside. Trends in Genetics, 35(2), 145-158. doi:10.1016/j.tig.2018.11.007en_US
dc.description.abstractChromatin interactions regulate gene expression by bringing distal regulatory elements, such as super-enhancers, to promoters in close spatial proximity. It has been recognized that in cancer, chromatin interactions can be dysregulated, leading to aberrant oncogene expression. Chromatin interactions may potentially serve as biomarkers, or be modulated via CRISPR therapy and small molecule inhibitors against transcription. However, these methods face challenges that must be resolved and raise questions for further research. Understanding chromatin interactions is essential for safety aspects of anticancer therapies, such as the mechanism of action of epigenetic regulators and transcription factors in cancer, and potential off-target effects arising from targeting super-enhancers and promoters. In this review article, we discuss how chromatin interactions and regulatory elements may become dysregulated in cancer, potential methods to target them for clinical therapy, and outline outstanding questions that require addressing before epigenetic therapies can translate to the clinic safely and effectively.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.relationMOE2014- T3-1-006en_US
dc.relation.ispartofTrends in Geneticsen_US
dc.relation.ispartofseriesTrends in Geneticsen
dc.rights© 2018 Elsevier Ltd. All rights reserved. This paper was published in Trends in Genetics and is made available with permission of Elsevier Ltd.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleChromatin interactions and regulatory elements in cancer : from bench to bedsideen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.versionAccepted versionen_US
dc.subject.keywordsChromatin Interactionsen_US
dc.description.acknowledgementThis research is supported by the National Research Foundation (NRF) Singapore through an NRF Fellowship awarded to M.J.F (NRF-NRFF2012-054). This research is supported by the RNA Biology Center at the Cancer Science Institute of Singapore, NUS, as part of funding under the Singapore Ministry of Education Academic Research Fund Tier 3 (MOE2014- T3-1-006). This research is supported by the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative.en_US
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