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Title: Chromatin interactions and regulatory elements in cancer : from bench to bedside
Authors: See, Yi Xiang
Wang, Benny Zhengjie
Fullwood, Melissa Jane
Keywords: Science::Biological sciences
Issue Date: 2018
Source: See, Y. X., Wang, B. Z., & Fullwood, M. J. (2019). Chromatin interactions and regulatory elements in cancer : from bench to bedside. Trends in Genetics, 35(2), 145-158. doi:10.1016/j.tig.2018.11.007
Project: NRF-NRFF2012-054
MOE2014- T3-1-006
Journal: Trends in Genetics
Series/Report no.: Trends in Genetics
Abstract: Chromatin interactions regulate gene expression by bringing distal regulatory elements, such as super-enhancers, to promoters in close spatial proximity. It has been recognized that in cancer, chromatin interactions can be dysregulated, leading to aberrant oncogene expression. Chromatin interactions may potentially serve as biomarkers, or be modulated via CRISPR therapy and small molecule inhibitors against transcription. However, these methods face challenges that must be resolved and raise questions for further research. Understanding chromatin interactions is essential for safety aspects of anticancer therapies, such as the mechanism of action of epigenetic regulators and transcription factors in cancer, and potential off-target effects arising from targeting super-enhancers and promoters. In this review article, we discuss how chromatin interactions and regulatory elements may become dysregulated in cancer, potential methods to target them for clinical therapy, and outline outstanding questions that require addressing before epigenetic therapies can translate to the clinic safely and effectively.
ISSN: 0168-9525
DOI: 10.1016/j.tig.2018.11.007
Schools: School of Biological Sciences 
Rights: © 2018 Elsevier Ltd. All rights reserved. This paper was published in Trends in Genetics and is made available with permission of Elsevier Ltd.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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