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|Title:||In vitro biocompatibility of diazirine-grafted biomaterials||Authors:||Djordjevic, Ivan
Steele, Terry W. J.
|Issue Date:||2020||Source:||Djordjevic, I., Wicaksono, G., Solic, I., & Steele, T. W. J. (2020). In vitro biocompatibility of diazirine-grafted biomaterials. Macromolecular Rapid Communications, 41(21), 2000235-. doi:10.1002/marc.202000235||Journal:||Macromolecular Rapid Communications||Abstract:||Photoactivation of aryl-diazirines is an emerging method of rapid, covalent crosslinking under ambient conditions. These attributes make those compounds candidates for grafting onto inert polymer backbones in order to produce stimuli-sensitive biomaterials. However, no risk assessments are available to gauge the toxicity of the leachable components after crosslinking activation. Herein, a stimuli-sensitive biomaterial is formulated from diazirine-grafted polycaprolactone tetrol. Also known as CaproGlu, this biomaterial undergoes UVA-activated crosslinking, with many positive attributes toward bioadhesive applications; hydrophobic, solvent-free, liquid at room temperature, and transitions into a foam biorubber after mild UVA illumination. As a model diazirine-grafted biomaterial, hydrolyzed CaproGlu leachates are evaluated for genotoxicity and skin sensitization, namely, Ames test, direct peptide reactivity, and ARE-Nrf2 luciferase assays. The degradation products of diazirine-mediated crosslinking observe little to no risk of in vitro genotoxicity or skin sensitization.||URI:||https://hdl.handle.net/10356/144482||ISSN:||1022-1336||DOI:||10.1002/marc.202000235||Rights:||This is the accepted version of the following article: Djordjevic, I., Wicaksono, G., Solic, I., & Steele, T. W. J. (2020). In vitro biocompatibility of diazirine grafted biomaterials. Macromolecular Rapid Communications, 41(21), 2000235-. doi:10.1002/marc.202000235. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-arhiving.html].||Fulltext Permission:||embargo_20211130||Fulltext Availability:||With Fulltext|
|Appears in Collections:||MSE Journal Articles|
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|1.34 MB||Adobe PDF||Under embargo until Nov 30, 2021|
Updated on Jan 26, 2021
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