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Title: In vitro biocompatibility of diazirine-grafted biomaterials
Authors: Djordjevic, Ivan
Wicaksono, Gautama
Solic, Ivan
Steele, Terry W. J.
Keywords: Engineering::Materials::Biomaterials
Issue Date: 2020
Source: Djordjevic, I., Wicaksono, G., Solic, I., & Steele, T. W. J. (2020). In vitro biocompatibility of diazirine-grafted biomaterials. Macromolecular Rapid Communications, 41(21), 2000235-. doi:10.1002/marc.202000235
Journal: Macromolecular Rapid Communications
Abstract: Photoactivation of aryl-diazirines is an emerging method of rapid, covalent crosslinking under ambient conditions. These attributes make those compounds candidates for grafting onto inert polymer backbones in order to produce stimuli-sensitive biomaterials. However, no risk assessments are available to gauge the toxicity of the leachable components after crosslinking activation. Herein, a stimuli-sensitive biomaterial is formulated from diazirine-grafted polycaprolactone tetrol. Also known as CaproGlu, this biomaterial undergoes UVA-activated crosslinking, with many positive attributes toward bioadhesive applications; hydrophobic, solvent-free, liquid at room temperature, and transitions into a foam biorubber after mild UVA illumination. As a model diazirine-grafted biomaterial, hydrolyzed CaproGlu leachates are evaluated for genotoxicity and skin sensitization, namely, Ames test, direct peptide reactivity, and ARE-Nrf2 luciferase assays. The degradation products of diazirine-mediated crosslinking observe little to no risk of in vitro genotoxicity or skin sensitization.
ISSN: 1022-1336
DOI: 10.1002/marc.202000235
Rights: This is the accepted version of the following article: Djordjevic, I., Wicaksono, G., Solic, I., & Steele, T. W. J. (2020). In vitro biocompatibility of diazirine grafted biomaterials. Macromolecular Rapid Communications, 41(21), 2000235-. doi:10.1002/marc.202000235. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [].
Fulltext Permission: embargo_20211130
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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