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Title: Electrochemical and optical CMOS sensors design for biochemical detection
Authors: Jiang, Yu
Keywords: Engineering::Electrical and electronic engineering::Integrated circuits
Issue Date: 2020
Publisher: Nanyang Technological University
Source: Jiang, Y. (2020). Electrochemical and optical CMOS sensors design for biochemical detection. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Population ageing has driven the incremental demands on portable and cost-efficient point-of-care diagnostics. However, most of the existing techniques require bulky and expensive high-end instruments. New methods based on CMOS sensors are possible solutions. In this thesis, three types of CMOS sensors are studied for biochemical detection: CMOS ion-sensitive field-effect transistor (ISFET) sensor for food safety screening, CMOS chronocoulometric sensor for the heavy metal monitor, and CMOS fluorescence sensor for near-infrared quantum dots detection. In-depth understanding of these novel CMOS sensors is presented here from working principles, circuit designs, to the experimental results. Sub-threshold amplifier and capacitive transimpedance amplifier (CTIA) are proposed to realize a high-sensitivity detection. Correlated double sampling (CDS) and pixel calibration are employed to reduce the variations in an array. The demonstrated CMOS biosensors are low-cost and miniaturized. They could become promising in personalized biomedical tests in future.
DOI: 10.32657/10356/144512
Schools: School of Electrical and Electronic Engineering 
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Theses

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