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Title: A simple strategy to enhance the in vivo wound-healing activity of curcumin in the form of self-assembled nanoparticle complex of curcumin and oligochitosan
Authors: Nguyen, Minh-Hiep
Lee, Suen Ern
Tran, The-Thien
Bui, Chi-Bao
Nguyen, Thi-Huynh-Nga
Vu, Ngoc-Bich-Dao
Tran, Thi-Thuy
Nguyen, Trong-Hoanh-Phong
Nguyen, Thi-Thu
Hadinoto, Kunn
Keywords: Engineering::Chemical engineering
Issue Date: 2018
Source: Nguyen, M.-H., Lee, S. E., Tran, T.-T., Bui, C.-B., Nguyen, T.-H.-N., Vu, N.-B.-D., ... Hadinoto, K. (2019). A simple strategy to enhance the in vivo wound-healing activity of curcumin in the form of self-assembled nanoparticle complex of curcumin and oligochitosan. Materials Science and Engineering: C, 98, 54-64. doi:10.1016/j.msec.2018.12.091
Journal: Materials Science and Engineering: C
Abstract: While the wound healing activity of curcumin (CUR) has been well-established, its clinical effectiveness remains limited due to the inherently low aqueous CUR solubility, resulting in suboptimal CUR exposure in the wound sites. Previously, we developed high-payload amorphous nanoparticle complex (or nanoplex) of CUR and chitosan (CHI) capable of CUR solubility enhancement by drug-polyelectrolyte complexation. The CUR-CHI nanoplex, however, exhibited poor colloidal stability due to its strong agglomeration tendency. Herein we hypothesized that the colloidal stability could be improved by replacing CHI with its oligomers (OCHI) owed to the better charge distribution in OCHI. The effects of key parameters in drug-polyelectrolyte complexation (i.e. pH, salt inclusion, CUR concentration, and OCHI/CUR charge ratio) on the physical characteristics and preparation efficiency of the CUR-OCHI nanoplex produced were investigated. The in vivo wound healing efficacy of the CUR-OCHI nanoplex and its cytotoxicity towards human keratinocytes cells were examined. The results showed that CUR-OCHI nanoplex exhibited prolonged colloidal stability (72 h versus <24 h for the CUR-CHI nanoplex). At the optimal condition, the CUR-OCHI nanoplex (without ultrasonication) exhibited size, zeta potential, and CUR payload of ≈140 nm, 20 mV, and 78% (w/w), respectively. The nanoplex preparation was simple yet robust at nearly 100% CUR utilization rate. The CUR-OCHI nanoplex exhibited superior wound healing efficacy to the native CUR with wound closure of >90% after 7 days versus 9 days for the native CUR resulting in smaller scars, attributed to its generation of high CUR concentration in the wound sites.
ISSN: 0928-4931
DOI: 10.1016/j.msec.2018.12.091
Rights: © 2018 Elsevier B.V. All rights reserved. This paper was published in Materials Science and Engineering: C and is made available with permission of Elsevier B.V.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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