Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/144604
Title: Controlled reduction of carboxamides to alcohols or amines by zinc hydrides
Authors: Ong, Derek Yiren
Yen, Zhihao
Yoshii, Asami
Imbernon, Julia Revillo
Takita, Ryo
Chiba, Shunsuke
Keywords: Science::Chemistry
Issue Date: 2019
Source: Ong, D. Y., Yen, Z., Yoshii, A., Imbernon, J. R., Takita, R., & Chiba, S. (2019). Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides. Angewandte Chemie International Edition, 58(15), 4992–4997. doi:10.1002/anie.201900233
Journal: Angewandte Chemie International Edition
Abstract: New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination of sodium hydride (NaH) and zinc halides (ZnX2 ). Use of a different halide on ZnX2 dictates the selectivity, wherein the NaH-ZnI2 system delivers alcohols and NaH-ZnCl2 gives amines. Extensive mechanistic studies by experimental and theoretical approaches imply that polymeric zinc hydride (ZnH2 )∞ is responsible for alcohol formation, whereas dimeric zinc chloride hydride (H-Zn-Cl)2 is the key species for the production of amines.
URI: https://hdl.handle.net/10356/144604
ISSN: 1433-7851
DOI: 10.1002/anie.201900233
Rights: This is the accepted version of the following article: Ong, D. Y., Yen, Z., Yoshii, A., Imbernon, J. R., Takita, R., & Chiba, S. (2019). Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides. Angewandte Chemie International Edition, 58(15), 4992–4997., which has been published in final form at doi:10.1002/anie.201900233. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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