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https://hdl.handle.net/10356/144604| Title: | Controlled reduction of carboxamides to alcohols or amines by zinc hydrides | Authors: | Ong, Derek Yiren Yen, Zhihao Yoshii, Asami Imbernon, Julia Revillo Takita, Ryo Chiba, Shunsuke |
Keywords: | Science::Chemistry | Issue Date: | 2019 | Source: | Ong, D. Y., Yen, Z., Yoshii, A., Imbernon, J. R., Takita, R., & Chiba, S. (2019). Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides. Angewandte Chemie International Edition, 58(15), 4992–4997. doi:10.1002/anie.201900233 | Journal: | Angewandte Chemie International Edition | Abstract: | New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination of sodium hydride (NaH) and zinc halides (ZnX2 ). Use of a different halide on ZnX2 dictates the selectivity, wherein the NaH-ZnI2 system delivers alcohols and NaH-ZnCl2 gives amines. Extensive mechanistic studies by experimental and theoretical approaches imply that polymeric zinc hydride (ZnH2 )∞ is responsible for alcohol formation, whereas dimeric zinc chloride hydride (H-Zn-Cl)2 is the key species for the production of amines. | URI: | https://hdl.handle.net/10356/144604 | ISSN: | 1433-7851 | DOI: | 10.1002/anie.201900233 | Rights: | This is the accepted version of the following article: Ong, D. Y., Yen, Z., Yoshii, A., Imbernon, J. R., Takita, R., & Chiba, S. (2019). Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides. Angewandte Chemie International Edition, 58(15), 4992–4997., which has been published in final form at doi:10.1002/anie.201900233. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html]. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SPMS Journal Articles |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc hydrides.pdf | 1.17 MB | Adobe PDF | View/Open |
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