Please use this identifier to cite or link to this item:
Title: Investigating the role of PPARβ/δ in retinal vascular remodeling using Pparβ/δ-deficient mice
Authors: Ho, Sze Yuan
Kwan, Yuet Ping
Qiu, Beiying
Tan, Alison
Murray, Hannah Louise
Barathi, Veluchamy Amutha
Tan, Nguan Soon
Cheung, Gemmy Chui Ming
Wong, Tien Yin
Wahli, Walter
Wang, Xiaomeng
Keywords: Science::Medicine
Issue Date: 2020
Source: Ho, S. Y., Kwan, Y. P., Qiu, B., Tan, A., Murray, H. L., Barathi, V. A., . . . Wang, X. (2020). Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice. International Journal of Molecular Sciences, 21(12), 4403-. doi:10.3390/ijms21124403
Journal: International journal of molecular sciences 
Abstract: Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Pparβ/δ-deficient mice. However, PPARβ/δ's role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Pparβ/δ-haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina.
ISSN: 1661-6596
DOI: 10.3390/ijms21124403
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
School of Biological Sciences 
Organisations: Institute of Molecular and Cell Biology, A*STAR
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

Files in This Item:
File Description SizeFormat 
Investigating the Role of PPAR in Retinal Vascular remodeling using ppar deficient mice.pdf1.59 MBAdobe PDFThumbnail

Citations 50

Updated on Jun 5, 2023

Web of ScienceTM
Citations 50

Updated on Jun 1, 2023

Page view(s)

Updated on Jun 6, 2023

Download(s) 50

Updated on Jun 6, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.