Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/144724
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dc.contributor.authorHo, Sze Yuanen_US
dc.contributor.authorKwan, Yuet Pingen_US
dc.contributor.authorQiu, Beiyingen_US
dc.contributor.authorTan, Alisonen_US
dc.contributor.authorMurray, Hannah Louiseen_US
dc.contributor.authorBarathi, Veluchamy Amuthaen_US
dc.contributor.authorTan, Nguan Soonen_US
dc.contributor.authorCheung, Gemmy Chui Mingen_US
dc.contributor.authorWong, Tien Yinen_US
dc.contributor.authorWahli, Walteren_US
dc.contributor.authorWang, Xiaomengen_US
dc.date.accessioned2020-11-20T08:04:24Z-
dc.date.available2020-11-20T08:04:24Z-
dc.date.issued2020-
dc.identifier.citationHo, S. Y., Kwan, Y. P., Qiu, B., Tan, A., Murray, H. L., Barathi, V. A., . . . Wang, X. (2020). Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice. International Journal of Molecular Sciences, 21(12), 4403-. doi:10.3390/ijms21124403en_US
dc.identifier.issn1661-6596en_US
dc.identifier.urihttps://hdl.handle.net/10356/144724-
dc.description.abstractPeroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Pparβ/δ-deficient mice. However, PPARβ/δ's role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Pparβ/δ-haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina.en_US
dc.language.isoenen_US
dc.relation.ispartofInternational journal of molecular sciencesen_US
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/)en_US
dc.subjectScience::Medicineen_US
dc.titleInvestigating the role of PPARβ/δ in retinal vascular remodeling using Pparβ/δ-deficient miceen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.organizationInstitute of Molecular and Cell Biology, A*STARen_US
dc.identifier.doi10.3390/ijms21124403-
dc.description.versionPublished versionen_US
dc.identifier.pmid32575793-
dc.identifier.issue12en_US
dc.identifier.volume21en_US
dc.subject.keywordsPPARβ/δen_US
dc.subject.keywordsAngiogenesisen_US
item.grantfulltextopen-
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Appears in Collections:LKCMedicine Journal Articles
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