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Title: Investigating the role of PPARβ/δ in retinal vascular remodeling using Pparβ/δ-deficient mice
Authors: Ho, Sze Yuan
Kwan, Yuet Ping
Qiu, Beiying
Tan, Alison
Murray, Hannah Louise
Barathi, Veluchamy Amutha
Tan, Nguan Soon
Cheung, Gemmy Chui Ming
Wong, Tien Yin
Wahli, Walter
Wang, Xiaomeng
Keywords: Science::Medicine
Issue Date: 2020
Source: Ho, S. Y., Kwan, Y. P., Qiu, B., Tan, A., Murray, H. L., Barathi, V. A., . . . Wang, X. (2020). Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice. International Journal of Molecular Sciences, 21(12), 4403-. doi:10.3390/ijms21124403
Journal: International journal of molecular sciences
Abstract: Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in Pparβ/δ-deficient mice. However, PPARβ/δ's role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in Pparβ/δ-haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina.
ISSN: 1661-6596
DOI: 10.3390/ijms21124403
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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