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Title: Hepatic PPARα is critical in the metabolic adaptation to sepsis
Authors: Paumelle, Réjane
Haas, Joel T.
Hennuyer, Nathalie
Baugé, Eric
Deleye, Yann
Mesotten, Dieter
Langouche, Lies
Vanhoutte, Jonathan
Cudejko, Céline
Wouters, Kristiaan
Hannou, Sarah Anissa
Legry, Vanessa
Lancel, Steve
Lalloyer, Fanny
Polizzi, Arnaud
Smati, Sarra
Gourdy, Pierre
Vallez, Emmanuelle
Bouchaert, Emmanuel
Derudas, Bruno
Dehondt, Hélène
Gheeraert, Céline
Fleury, Sébastien
Tailleux, Anne
Montagner, Alexandra
Wahli, Walter
Van Den Berghe, Greet
Guillou, Hervé
Dombrowicz, David
Staels, Bart
Keywords: Science::Medicine
Issue Date: 2019
Source: Paumelle, R., Haas, J. T., Hennuyer, N., Baugé, E., Deleye, Y., Mesotten, D., . . . Staels, B. (2019). Hepatic PPARα is critical in the metabolic adaptation to sepsis. Journal of Hepatology, 70(5), 963-973. doi:10.1016/j.jhep.2018.12.037
Journal: Journal of Hepatology
Abstract: Although the role of inflammation to combat infection is known, the contribution of metabolic changes in response to sepsis is poorly understood. Sepsis induces the release of lipid mediators, many of which activate nuclear receptors such as the peroxisome proliferator-activated receptor (PPAR)α, which controls both lipid metabolism and inflammation. We aimed to elucidate the previously unknown role of hepatic PPARα in the response to sepsis.
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2018.12.037
Rights: © 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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