Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/144861
Title: Realizing a record photothermal conversion efficiency of spiky gold nanoparticles in the second near-infrared window by structure-based rational design
Authors: Bi, Cuixia
Chen, Jin
Chen, Ying
Song, Yahui
Li, Anran
Li, Shuzhou
Mao, Zhengwei
Gao, Changyou
Wang, Dayang
Möhwald, Helmuth
Xia, Haibing
Keywords: Engineering::Materials
Issue Date: 2018
Source: Bi, C., Chen, J., Chen, Y., Song, Y., Li, A., Li, S., ... Xia, H. (2018). Realizing a record photothermal conversion efficiency of spiky gold nanoparticles in the second near-infrared window by structure-based rational design. Chemistry of Materials, 30(8), 2709-2718. doi:10.1021/acs.chemmater.8b00312
Journal: Chemistry of Materials
Abstract: The current technical dilemma for gold nanoparticles as photothermal (PT) transducers in cancer therapy is that strong absorption in the second near-infrared (NIR) window is accompanied by strong scattering of the NIR light, which then overrides the absorption, thus significantly weakening the light-to-heat conversion efficiency. Here we successfully prepared spiky gold nanoparticles (spiky Au NPs) with a controlled number of spikes, designed according to our simulations and experimentally verified. Their overall sizes and the numbers, lengths, and widths of the spikes were judiciously adjusted to locate their surface plasmon resonance peaks in the second NIR window and also to achieve a higher absorption-to-extinction ratio. As a result, the spiky Au NPs with optimal size and 6 spikes exhibited a record light-to-heat conversion efficiency (78.8%) under irradiation by 980 nm light. After surface PEGylation and conjugation with a lactoferrin (LF) ligand on the resulting spiky Au NPs, they in vivo displayed long circulation time (blood circulation half-life of ∼300 min) and high tumor accumulation due to their larger surface-to-volume ratio. Therefore, spiky Au NPs allowed complete ablation of tumors without recurrence merely after 3 min of light irradiation at 980 nm, opening up promising prospects of cancer photothermal therapy.
URI: https://hdl.handle.net/10356/144861
ISSN: 1520-5002
DOI: 10.1021/acs.chemmater.8b00312
Rights: © 2018 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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