Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/144898
Title: Advanced near‐infrared light‐responsive nanomaterials as therapeutic platforms for cancer therapy
Authors: Chien, Yi-Hsin
Chan, Kok Ken
Anderson, Tommy
Kong, Kien Voon
Ng, Beng Koon
Yong, Ken-Tye
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2018
Source: Chien, Y.-H., Chan, K. K., Anderson, T., Kong, K. V., Ng, B. K., & Yong, K.-T. (2019). Advanced near‐infrared light‐responsive nanomaterials as therapeutic platforms for cancer therapy. Advanced Therapeutics, 2(3), 1800090-. doi:10.1002/adtp.201800090
Journal: Advanced Therapeutics
Abstract: Cancer is one of the leading causes of death. Despite the huge progress in the field of cancer drugs and therapies, the treatment outcome is still bleak for most cancer patients. Nanotechnology has revolutionized cancer therapeutics. By using nano‐sized particles as delivery systems, therapeutic biomolecules are transported efficiently to the target sites. Moreover, these particles are designed to carry out multiple cancer treatments simultaneously. Near‐infrared (NIR) light‐responsive nanomaterials have gained much attention as NIR light has a greater penetration depth, minimal phototoxicity, lower autofluorescence, and reduced light scattering. Among the available NIR light‐responsive nanomaterials, gold nanorods, upconversion nanoparticles, carbon dots, transition metal dichalcogenide, metal oxides, black phosphorus, and polymeric nanomaterials have become attractive options owing to their excellent optical properties, ease of synthesis and modification, outstanding photodynamic and photothermal conversion properties, and most importantly, favorable toxicity level and biocompatibility which are prerequisites for biological applications. In this review, the outstanding properties, synthesis, and surface functionalization of the aforementioned NIR light‐responsive nanomaterials are introduced in detail. Recent advances of these nanomaterials for various cancer treatment modalities are summarized to highlight their versatility and potential in cancer theranostics. Finally, a perspective is proposed on future research directions and their clinical translation.
URI: https://hdl.handle.net/10356/144898
ISSN: 2366-3987
DOI: 10.1002/adtp.201800090
Rights: This is the accepted version of the following article: Chien, Y.-H., Chan, K. K., Anderson, T., Kong, K. V., Ng, B. K., & Yong, K.-T. (2019). Advanced near‐infrared light‐responsive nanomaterials as therapeutic platforms for cancer therapy. Advanced Therapeutics, 2(3), 1800090-. doi:10.1002/adtp.201800090, which has been published in final form at https://doi.org/10.1002/adtp.201800090. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].
Fulltext Permission: open
Fulltext Availability: With Fulltext
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