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Title: Peroxisome proliferator-activated receptors and caloric restriction-common pathways affecting metabolism, health, and longevity
Authors: Duszka, Kalina
Gregor, András
Guillou, Hervé
König, Jürgen
Wahli, Walter
Keywords: Science::Medicine
Issue Date: 2020
Source: Duszka, K., Gregor, A., Guillou, H., König, J., & Wahli, W. (2020). Peroxisome Proliferator-Activated Receptors and Caloric Restriction—Common Pathways Affecting Metabolism, Health, and Longevity. Cells, 9(7), 1708-. doi:10.3390/cells9071708
Journal: Cells
Abstract: Caloric restriction (CR) is a traditional but scientifically verified approach to promoting health and increasing lifespan. CR exerts its effects through multiple molecular pathways that trigger major metabolic adaptations. It influences key nutrient and energy-sensing pathways including mammalian target of rapamycin, Sirtuin 1, AMP-activated protein kinase, and insulin signaling, ultimately resulting in reductions in basic metabolic rate, inflammation, and oxidative stress, as well as increased autophagy and mitochondrial efficiency. CR shares multiple overlapping pathways with peroxisome proliferator-activated receptors (PPARs), particularly in energy metabolism and inflammation. Consequently, several lines of evidence suggest that PPARs might be indispensable for beneficial outcomes related to CR. In this review, we present the available evidence for the interconnection between CR and PPARs, highlighting their shared pathways and analyzing their interaction. We also discuss the possible contributions of PPARs to the effects of CR on whole organism outcomes.
ISSN: 0092-8674
DOI: 10.3390/cells9071708
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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