Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/144957
Title: Magnetic digital microfluidics on a bioinspired surface for point-of-care diagnostics of infectious disease
Authors: Kanitthamniyom, Pojchanun
Zhang, Yi
Keywords: Engineering::Mechanical engineering
Issue Date: 2019
Source: Kanitthamniyom, P., & Zhang, Y. (2019). Magnetic digital microfluidics on a bioinspired surface for point‐of‐care diagnostics of infectious disease. ELECTROPHORESIS, 40(8), 1178–1185. doi:10.1002/elps.201900074
Journal: Electrophoresis
Abstract: Magnetic digital microfluidics uses magnetic force to manipulate droplets on a Teflon-coated substrate through the added magnetic particles. To achieve a wide range of droplet manipulation, hydrophilic patterns, known as surface energy traps, are introduced onto the Teflon-coated hydrophobic substrate. However, the Teflon-coated substrate is difficult to modify because it is nonwettable, and existing techniques for patterning surface energy traps have many limitations. Inspired by the mussel adhesion mechanism, we use polydopamine, a bioinspired substance that adheres strongly to almost any materials, to pattern surface energy traps on the Teflon-coated substrate with a great ease. We have optimized the polydopamine coating protocol and characterized the surface properties of the polydopamine surface energy traps. Droplet operations including particle extraction, liquid dispensing, liquid shaping, and cross-platform transfer have been demonstrated on the polydopamine surface energy trap-enabled magnetic digital microfluidic platform in both single-plate and two-plate configurations. Furthermore, the detection of hepatitis B surface antigen using ELISA has been demonstrated on the new magnetic dgitial microfluidic platform. This new bioinspired magnetic digital microfluidic platform is easy to fabricate and operate, showing a great potential for point-of-care applications.
URI: https://hdl.handle.net/10356/144957
ISSN: 0173-0835
DOI: 10.1002/elps.201900074
Rights: This is the accepted version of the following article: Kanitthamniyom, P., & Zhang, Y. (2019). Magnetic digital microfluidics on a bioinspired surface for point‐of‐care diagnostics of infectious disease. ELECTROPHORESIS, 40(8), 1178–1185., which has been published in final form at doi:10.1002/elps.201900074. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles

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