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dc.contributor.authorGoh, Chi Chingen_US
dc.contributor.authorEvrard, Maximilienen_US
dc.contributor.authorChong, Shu Zhenen_US
dc.contributor.authorTan, Yingrouen_US
dc.contributor.authorTan, Leonard De Lien_US
dc.contributor.authorTeng, Karen Wei Wengen_US
dc.contributor.authorWeninger, Wolfgangen_US
dc.contributor.authorBecker, David Laurenceen_US
dc.contributor.authorTey, Hong Liangen_US
dc.contributor.authorNewell, Evan Williamen_US
dc.contributor.authorLiu, Binen_US
dc.contributor.authorNg, Lai Guanen_US
dc.identifier.citationGoh, C. C., Evrard, M., Chong, S. Z., Tan, Y., Tan, L. D. L., Teng, K. W. W., ... Ng, L. G. (2018). The impact of ischemia-reperfusion injuries on skin resident murine dendritic cells. European Journal of Immunology, 48(6), 1014-1019. doi:10.1002/eji.201747347en_US
dc.description.abstractPressure ulcers are a chronic problem for patients or the elderly who require extended periods of bed rest. The formation of ulcers is due to repeated cycles of ischemia-reperfusion (IR), which initiates an inflammatory response. Advanced ulcers disrupt the skin barrier, resulting in further complications. To date, the immunological aspect of skin IR has been understudied, partly due to the complexity of the skin immune cells. Through a combination of mass cytometry, confocal imaging and intravital multiphoton imaging, this study establishes a workflow for multidimensionality single cell analysis of skin myeloid cell responses in the context of IR injury with high spatiotemporal resolution. The data generated has provided us with previously uncharacterized insights into the distinct cellular behavior of resident dendritic cells (DCs) and recruited neutrophils post IR. Of interest, we observed a drop in DDC numbers in the IR region, which was subsequently replenished 48h post IR. More importantly, in these cells, we observe an attenuated response to repeated injuries, which may have implications in the subsequent wound healing process.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.relation.ispartofEuropean Journal of Immunologyen_US
dc.rights© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.en_US
dc.titleThe impact of ischemia-reperfusion injuries on skin resident murine dendritic cellsen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.subject.keywordsDendritic Cellsen_US
dc.description.acknowledgementWe thank Dr. Michel Nussenzweig and Dr. Thomas Graf for providing us with the CD11c‐EYFP and LysM‐ eGFP mice, respectively. This research was funded by SIgN core funding, A*STAR, Singapore and National Health and Medical Research Council, Australia (1106439 to W.W. and L.G. NG).en_US
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