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Title: The impact of ischemia-reperfusion injuries on skin resident murine dendritic cells
Authors: Goh, Chi Ching
Evrard, Maximilien
Chong, Shu Zhen
Tan, Yingrou
Tan, Leonard De Li
Teng, Karen Wei Weng
Weninger, Wolfgang
Becker, David Laurence
Tey, Hong Liang
Newell, Evan William
Liu, Bin
Ng, Lai Guan
Keywords: Science::Medicine
Issue Date: 2018
Source: Goh, C. C., Evrard, M., Chong, S. Z., Tan, Y., Tan, L. D. L., Teng, K. W. W., ... Ng, L. G. (2018). The impact of ischemia-reperfusion injuries on skin resident murine dendritic cells. European Journal of Immunology, 48(6), 1014-1019. doi:10.1002/eji.201747347
Journal: European Journal of Immunology
Abstract: Pressure ulcers are a chronic problem for patients or the elderly who require extended periods of bed rest. The formation of ulcers is due to repeated cycles of ischemia-reperfusion (IR), which initiates an inflammatory response. Advanced ulcers disrupt the skin barrier, resulting in further complications. To date, the immunological aspect of skin IR has been understudied, partly due to the complexity of the skin immune cells. Through a combination of mass cytometry, confocal imaging and intravital multiphoton imaging, this study establishes a workflow for multidimensionality single cell analysis of skin myeloid cell responses in the context of IR injury with high spatiotemporal resolution. The data generated has provided us with previously uncharacterized insights into the distinct cellular behavior of resident dendritic cells (DCs) and recruited neutrophils post IR. Of interest, we observed a drop in DDC numbers in the IR region, which was subsequently replenished 48h post IR. More importantly, in these cells, we observe an attenuated response to repeated injuries, which may have implications in the subsequent wound healing process.
ISSN: 1521-4141
DOI: 10.1002/eji.201747347
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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