Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/145258
Title: Hydrogen sulfide sensitizes Acinetobacter baumannii to killing by antibiotics
Authors: Ng, Say Yong
Ong, Kai Xun
Surendran, Smitha Thamarath
Sinha, Ameya
Lai, Joey Jia Hui
Chen, Jacqueline
Liang, Jiaqi
Tay, Leona Kwan Sing
Cui, Liang
Loo, Hooi Linn
Ho, Peiying
Han, Jongyoon
Moreira, Wilfried
Keywords: Science::Biological sciences
Issue Date: 2020
Source: Ng, S. Y., Ong, K. X., Surendran, S. T., Sinha, A., Lai, J. J. H., Chen, J., . . . Moreira, W. (2020). Hydrogen sulfide sensitizes Acinetobacter baumannii to killing by antibiotics. Frontiers in Microbiology, 11, 1875-. doi:10.3389/fmicb.2020.01875
Project: NMRC-OFYIRG-036-2017
Journal: Frontiers in Microbiology
Abstract: The production of endogenous hydrogen sulfide (H2S) has been shown to confer antibiotic tolerance in all bacteria studied to date. Therefore, this mediator has been speculated to be a universal defense mechanism against antibiotics in bacteria. This is assuming that all bacteria produce endogenous H2S. In this study, we established that the pathogenic bacteria Acinetobacter baumannii does not produce endogenous H2S, giving us the opportunity to test the effect of exogenous H2S on antibiotic tolerance in a bacterium that does not produce it. By using a H2S-releasing compound to modulate the sulfide content in A. baumannii, we demonstrated that instead of conferring antibiotic tolerance, exogenous H2S sensitized A. baumannii to multiple antibiotic classes, and was able to revert acquired resistance to gentamicin. Exogenous H2S triggered a perturbation of redox and energy homeostasis that translated into hypersensitivity to antibiotic killing. We propose that H2S could be used as an antibiotic-potentiator and resistance-reversion agent in bacteria that do not produce it.
URI: https://hdl.handle.net/10356/145258
ISSN: 1664-302X
DOI: 10.3389/fmicb.2020.01875
Rights: © 2020 Ng, Ong, Surendran, Sinha, Lai, Chen, Liang, Tay, Cui, Loo, Ho, Han and Moreira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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