Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/145297
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dc.contributor.authorSeishima, Ryoen_US
dc.contributor.authorBarker, Nicken_US
dc.date.accessioned2020-12-16T09:22:10Z-
dc.date.available2020-12-16T09:22:10Z-
dc.date.issued2019-
dc.identifier.citationSeishima, R., & Barker, N. (2019). A contemporary snapshot of intestinal stem cells and their regulation. Differentiation, 108, 3-7. doi:10.1016/j.diff.2019.01.004en_US
dc.identifier.issn0301-4681en_US
dc.identifier.urihttps://hdl.handle.net/10356/145297-
dc.description.abstractIntestinal stem cells (ISCs) marked by Lgr5 are located at the bottom of the epithelial crypt compartment. Canonical Wnt signaling, activated by Wnt/Rspo ligands, determines the stem cell identity of Lgr5 + ISCs and is strictly regulated by the ISC niche. Emerging evidence indicates that both epithelial and stromal compartments provide the requisite Wnt/Rspo ligands, confining the ISC niche to the lower crypt regions of the intestine. Recent studies have also shown that the ISC niche can reprogram differentiated cells to replenish lost ISCs following tissue injury, accounting for the epithelial cell plasticity within the crypt compartment. Here we review these recent advances and discuss the role of canonical Wnt signaling in maintaining homeostasis and effecting cell plasticity following tissue injury in the intestine, which could reveal potential novel therapeutic opportunities in the clinic.en_US
dc.language.isoenen_US
dc.relation.ispartofDifferentiationen_US
dc.rights© 2019 International Society of Differentiation. All rights reserved. This paper was published by Elsevier B.V. in Differentiation and is made available with permission of International Society of Differentiation.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleA contemporary snapshot of intestinal stem cells and their regulationen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.organizationInstitute of Medical Biology, A*STARen_US
dc.identifier.doi10.1016/j.diff.2019.01.004-
dc.description.versionAccepted versionen_US
dc.identifier.pmid30711339-
dc.identifier.volume108en_US
dc.identifier.spage3en_US
dc.identifier.epage7en_US
dc.subject.keywordsIntestinal Stem Cellen_US
dc.subject.keywordsWnt Signalingen_US
item.grantfulltextopen-
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