Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/145308
Title: Female rats are resilient to the behavioral effects of maternal separation stress and exhibit stress-induced neurogenesis
Authors: Lee, Yan Jun
Koe, Amelia S.
Ashokan, Archana
Mitra, Rupshi
Keywords: Science::Biological sciences
Issue Date: 2020
Source: Lee, Y. J., Koe, A. S., Ashokan, A., & Mitra, R. (2020). Female rats are resilient to the behavioral effects of maternal separation stress and exhibit stress-induced neurogenesis. Heliyon, 6(8), e04753-. doi:10.1016/j.heliyon.2020.e04753
Project: RG 46/12
Journal: Heliyon
Abstract: Early-life stress causes anxiogenesis and sensitivity of stress endocrine axis, facilitated by changes in the basolateral amygdala and hippocampal neurogenesis. In this report, we examined if male-like relationship between early-life stress and anxiety was recapitulated in female rats, along with related neurobiological substrates of the amygdala and the hippocampus. Maternal separation, a paradigm consistently utilized in male rats in most previously published scripts, did not cause similar behavioral consequences in females. Maternal separation caused an increase in adult hippocampal neurogenesis in females without causing substantial differences in dendritic arbors of the basolateral amygdala. Thus, female rats displayed remarkable resilience in the emotional consequences of early-life stress.
URI: https://hdl.handle.net/10356/145308
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2020.e04753
Rights: © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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