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Title: Acquisition of plasmid with carbapenem-resistance gene blaKPC2 in hypervirulent Klebsiella pneumoniae, Singapore
Authors: Chen, Yahua
Marimuthu, Kalisvar
Teo, Jeanette
Venkatachalam, Indumathi
Cherng, Benjamin Pei Zhi
Wang, Liang De
Prakki, Sai Rama Sridatta
Xu, Weizhen
Tan, Yi Han
Nguyen, Lan Chi
Koh, Tse Hsien
Ng, Oon Tek
Gan, Yunn-Hwen
Keywords: Science::Medicine
Issue Date: 2020
Source: Chen, Y., Marimuthu, K., Teo, J., Venkatachalam, I., Cherng, B. P. Z., Wang, L. D., . . . Gan, Y.-H. (2020). Acquisition of plasmid with carbapenem-resistance gene blaKPC2 in hypervirulent Klebsiella pneumoniae, Singapore. Emerging Infectious Diseases, 26(3), 549-559. doi:10.3201/eid2603.191230
Project: CoSTAR-HS, HS/ARGSeedGrant/2017/03
NMRC CGAug16C005
Journal: Emerging Infectious Diseases
Abstract: The convergence of carbapenem-resistance and hypervirulence genes in Klebsiella pneumoniae has led to the emergence of highly drug-resistant superbugs capable of causing invasive disease. We analyzed 556 carbapenem-resistant K. pneumoniae isolates from patients in Singapore hospitals during 2010-2015 and discovered 18 isolates from 7 patients also harbored hypervirulence features. All isolates contained a closely related plasmid (pKPC2) harboring blaKPC-2, a K. pneumoniae carbapenemase gene, and had a hypervirulent background of capsular serotypes K1, K2, and K20. In total, 5 of 7 first patient isolates were hypermucoviscous, and 6 were virulent in mice. The pKPC2 was highly transmissible and remarkably stable, maintained in bacteria within a patient with few changes for months in the absence of antimicrobial drug selection pressure. Intrapatient isolates were also able to acquire additional antimicrobial drug resistance genes when inside human bodies. Our results highlight the potential spread of carbapenem-resistant hypervirulent K. pneumoniae in Singapore.
ISSN: 1080-6040
DOI: 10.3201/eid2603.191230
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2020 The Author(s) (published by Public Domain). This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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