Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/145349
Title: Inter-relationship between ageing, body mass index, diabetes, systemic blood pressure and intraocular pressure in Asians : 6-year longitudinal study
Authors: Chua, Jacqueline
Chee, Miao Li
Chin, Calvin Woon Loong
Tham, Yih Chung
Tan, Nicholas
Lim, Sing Hui
Aung, Tin
Cheng, Ching-Yu
Wong, Tien Yin
Schmetterer, Leopold
Keywords: Science::Medicine
Issue Date: 2019
Source: Chua, J., Chee, M. L., Chin, C. W. L., Tham, Y. C., Tan, N., Lim, S. H., . . . Schmetterer, L. (2018). Inter-relationship between ageing, body mass index, diabetes, systemic blood pressure and intraocular pressure in Asians : 6-year longitudinal study. British Journal of Ophthalmology, 103(2), 196–202. doi:10.1136/bjophthalmol-2018-311897
Project: 0796/2003
IRG07nov013
RG09nov014
STaR/0003/2008
CG/SERI/2010
CG/C010A/2017
08/1/35/19/550
09/1/35/19/616
NMRC/CSA/033/2012
Journal: The British journal of ophthalmology
Abstract: Background: To investigate the biological effect of ageing on intraocular pressure (IOP) and risk factors in a population-based cohort study of Malay and Indian adults. Methods: Participants aged 40–80 years were recruited for baseline and 6-year follow-up visits between 2004–2009 and 2010–2015, respectively. Blood pressure (BP) was measured with an automatic BP monitor and IOP were obtained by Goldmann applanation tonometry. Main outcome was change in IOP, defined as the difference between the 6-year IOP and the baseline IOP. Linear regression models were used to investigate the association of changes in IOP with risk factors. Results: Participants without a history of glaucoma or cataract surgery at baseline were included (n = 3188; mean age: 54±9 years) . Their average IOP was reduced (−0.5±3.1 mm Hg), except for those who developed hypertension at follow-up (0.0±3.1 mm Hg). After adjusting for covariates, changes in IOP were negatively associated with age (β=−0.07, 95% CI −0.13 to −0.01) and positively associated with body mass index, diabetes, hypertension (normotensive as reference group; newly developed hypertensive (β=0.67, 95% CI 0.39 to 0.95) and chronic hypertensive (β=0.46, 95% CI 0.22 to 0.70)), baseline systolic BP (SBP) (β=0.20, 95% CI 0.14 to 0.26) and diastolic BP (DBP) (β=0.33, 95% CI 0.22 to 0.44), as well as with 6-year increases in SBP (β=0.27, 95% CI 0.21 to 0.33) and DBP (β=0.52, 95% CI 0.41 to 0.63). Conclusions Normal ageing and reduced systemic BP are associated with reduced IOP in Malay and Indian adults. Given that high IOP is a risk factor for glaucoma, our finding highlights the importance of controlling hypertension in older adults, where hypertension and glaucoma incidences are on a rise.
URI: https://hdl.handle.net/10356/145349
ISSN: 0007-1161
DOI: 10.1136/bjophthalmol-2018-311897
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2019 Author(s) (or their employer(s)). Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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