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Title: Heparan sulfate proteoglycans : key mediators of stem cell function
Authors: Ravikumar, Maanasa
Smith, Raymond Alexander Alfred
Nurcombe, Victor
Cool, Simon M.
Keywords: Science::Medicine
Issue Date: 2020
Source: Ravikumar, M., Smith, R. A. A., Nurcombe, V., & Cool, S. M. (2020). Heparan sulfate proteoglycans : key mediators of stem cell function. Frontiers in Cell and Developmental Biology, 8, 581213-. doi:10.3389/fcell.2020.581213
Project: H18/01/a0/021
Journal: Frontiers in Cell and Developmental Biology
Abstract: Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass ofglycoproteins with exquisite structural complexity. They are ubiquitously expressedacross tissues and have been found to exert a multitude of effects on cell behaviorand the surrounding microenvironment. Evidence has shown that heterogeneity inHSPG composition is crucial to its functions as an essential scaffolding componentin the extracellular matrix as well as a vital cell surface signaling co-receptor. Here,we provide an overview of the significance of HSPGs as essential regulators of stemcell function. We discuss the various roles of HSPGs in distinct stem cell typesduring key physiological events, from development through to tissue homeostasisand regeneration. The contribution of aberrant HSPG production to altered stemcell properties and dysregulated cellular homeostasis characteristic of cancer is alsoreviewed. Finally, we consider approaches to better understand and exploit themultifaceted functions of HSPGs in influencing stem cell characteristics for cell therapyand associated culture expansion strategies.
ISSN: 2296-634X
DOI: 10.3389/fcell.2020.581213
Rights: © 2020 Ravikumar, Smith, Nurcombe and Cool. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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