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|Title:||Dynamic networks observed in the nucleosome core particles couple the histone globular domains with DNA||Authors:||Shi, Xiangyan
|Keywords:||Science::Biological sciences||Issue Date:||2020||Source:||Shi, X., Prasanna, C., Soman, A., Pervushin, K., & Nordenskiöld, L. (2020). Dynamic networks observed in the nucleosome core particles couple the histone globular domains with DNA. Communications Biology, 3(1), 639-. doi:10.1038/s42003-020-01369-3||Project:||MOE2018-T2-1-112
|Journal:||Communications Biology||Abstract:||The dynamics of eukaryotic nucleosomes are essential in gene activity and well regulated by various factors. Here, we elucidated the internal dynamics at multiple timescales for the human histones hH3 and hH4 in the Widom 601 nucleosome core particles (NCP), suggesting that four dynamic networks are formed by the residues exhibiting larger-scale μs-ms motions that extend from the NCP core to the histone tails and DNA. Furthermore, despite possessing highly conserved structural features, histones in the telomeric NCP exhibit enhanced μs-ms dynamics in the globular sites residing at the identified dynamic networks and in a neighboring region. In addition, higher mobility was observed for the N-terminal tails of hH3 and hH4 in the telomeric NCP. The results demonstrate the existence of dynamic networks in nucleosomes, through which the center of the core regions could interactively communicate with histone tails and DNA to potentially propagate epigenetic changes.||URI:||https://hdl.handle.net/10356/145367||ISSN:||2399-3642||DOI:||10.1038/s42003-020-01369-3||Rights:||© 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SPMS Journal Articles|
Updated on Jun 24, 2022
Updated on Jun 24, 2022
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