Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/145372
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dc.contributor.authorNagaeva, Elinaen_US
dc.contributor.authorZubarev, Ivanen_US
dc.contributor.authorGonzales, Carolina Bengtssonen_US
dc.contributor.authorForss, Mikkoen_US
dc.contributor.authorNikouei, Kasraen_US
dc.contributor.authorde Miguel, Elenaen_US
dc.contributor.authorElsilä, Laurien_US
dc.contributor.authorLinden, Anni-Maijaen_US
dc.contributor.authorHjerling-Leffler, Jensen_US
dc.contributor.authorAugustine, George Jamesen_US
dc.contributor.authorKorpi, Esa R.en_US
dc.date.accessioned2020-12-18T08:26:52Z-
dc.date.available2020-12-18T08:26:52Z-
dc.date.issued2020-
dc.identifier.citationNagaeva, E., Zubarev, I., Gonzales, C. B., Forss, M., Nikouei, K., de Miguel, E., . . . Korpi, E. R. (2020). Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area. eLife, 9, 1-29. doi:10.7554/eLife.59328en_US
dc.identifier.issn2050-084Xen_US
dc.identifier.urihttps://hdl.handle.net/10356/145372-
dc.description.abstractThe cellular architecture of the ventral tegmental area (VTA), the main hub of the brain reward system, remains only partially characterized. To extend the characterization to inhibitory neurons, we have identified three distinct subtypes of somatostatin (Sst)-expressing neurons in the mouse VTA. These neurons differ in their electrophysiological and morphological properties, anatomical localization, as well as mRNA expression profiles. Importantly, similar to cortical Sst-containing interneurons, most VTA Sst neurons express GABAergic inhibitory markers, but some of them also express glutamatergic excitatory markers and a subpopulation even express dopaminergic markers. Furthermore, only some of the proposed marker genes for cortical Sst neurons were expressed in the VTA Sst neurons. Physiologically, one of the VTA Sst neuron subtypes locally inhibited neighboring dopamine neurons. Overall, our results demonstrate the remarkable complexity and heterogeneity of VTA Sst neurons and suggest that these cells are multifunctional players in the midbrain reward circuitry.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relationMOE2015-T2-2-095en_US
dc.relationMOE2017-T3-1-002en_US
dc.relation.ispartofeLifeen_US
dc.rights© 2020 Nagaeva et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.en_US
dc.subjectScience::Medicineen_US
dc.titleHeterogeneous somatostatin-expressing neuron population in mouse ventral tegmental areaen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.7554/eLife.59328-
dc.description.versionPublished versionen_US
dc.identifier.pmid32749220-
dc.identifier.volume9en_US
dc.identifier.spage1en_US
dc.identifier.epage29en_US
dc.subject.keywordsNeuronen_US
dc.subject.keywordsMidbrainen_US
dc.description.acknowledgementThe project was funded by the Academy of Finland (1278174 and 1317399), The Finnish National Agency for Education EDUFI, the Sigrid Juselius Foundation, and research grants MOE2015-T2-2-095 and MOE2017-T3-1-002 from the Singapore Ministry of Education. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.en_US
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