Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/145372
Title: Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area
Authors: Nagaeva, Elina
Zubarev, Ivan
Gonzales, Carolina Bengtsson
Forss, Mikko
Nikouei, Kasra
de Miguel, Elena
Elsilä, Lauri
Linden, Anni-Maija
Hjerling-Leffler, Jens
Augustine, George James
Korpi, Esa R.
Keywords: Science::Medicine
Issue Date: 2020
Source: Nagaeva, E., Zubarev, I., Gonzales, C. B., Forss, M., Nikouei, K., de Miguel, E., . . . Korpi, E. R. (2020). Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area. eLife, 9, 1-29. doi:10.7554/eLife.59328
Project: MOE2015-T2-2-095
MOE2017-T3-1-002
Journal: eLife
Abstract: The cellular architecture of the ventral tegmental area (VTA), the main hub of the brain reward system, remains only partially characterized. To extend the characterization to inhibitory neurons, we have identified three distinct subtypes of somatostatin (Sst)-expressing neurons in the mouse VTA. These neurons differ in their electrophysiological and morphological properties, anatomical localization, as well as mRNA expression profiles. Importantly, similar to cortical Sst-containing interneurons, most VTA Sst neurons express GABAergic inhibitory markers, but some of them also express glutamatergic excitatory markers and a subpopulation even express dopaminergic markers. Furthermore, only some of the proposed marker genes for cortical Sst neurons were expressed in the VTA Sst neurons. Physiologically, one of the VTA Sst neuron subtypes locally inhibited neighboring dopamine neurons. Overall, our results demonstrate the remarkable complexity and heterogeneity of VTA Sst neurons and suggest that these cells are multifunctional players in the midbrain reward circuitry.
URI: https://hdl.handle.net/10356/145372
ISSN: 2050-084X
DOI: 10.7554/eLife.59328
Rights: © 2020 Nagaeva et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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