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dc.contributor.authorLio, Daniel Chin Shiuanen_US
dc.contributor.authorChia, Ruiningen_US
dc.contributor.authorKwek, Milton Sheng Yien_US
dc.contributor.authorWiraja, Christianen_US
dc.contributor.authorMadden, Leigh Edwarden_US
dc.contributor.authorChang, Haoen_US
dc.contributor.authorS. Mohideen Abdul Khadiren_US
dc.contributor.authorWang, Xiaomengen_US
dc.contributor.authorBecker, David Lawrenceen_US
dc.contributor.authorXu, Chenjieen_US
dc.identifier.citationLio, D. C. S., Chia, R., Kwek, M. S. Y., Wiraja, C., Madden, L. E., Chang, H., . . . Xu, C. (2020). Temporal pressure enhanced topical drug delivery through micropore formation. Science Advances, 6(22), eaaz6919-. doi:10.1126/sciadv.aaz6919en_US
dc.description.abstractTransdermal drug delivery uses chemical, physical, or biochemical enhancers to cross the skin barrier. However, existing platforms require high doses of chemical enhancers or sophisticated equipment, use fragile biomolecules, or are limited to a certain type of drug. Here, we report an innovative methodology based on temporal pressure to enhance the penetration of all kinds of drugs, from small molecules to proteins and nanoparticles (up to 500 nm). The creation of micropores (~3 μm2) on the epidermal layer through a temporal pressure treatment results in the elevated expression of gap junctions, and reduced expression of occludin tight junctions. A 1 min treatment of 0.28-MPa allows nanoparticles (up to 500 nm) and macromolecules (up to 20 kDa) to reach a depth of 430-μm into the dermal layer. Using, as an example, the delivery of insulin through topical application after the pressure treatment yields up to 80% drop in blood glucose in diabetic mice.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.description.sponsorshipSkin Research Institute of Singapore (SRIS)en_US
dc.relation.ispartofScience Advancesen_US
dc.rights© 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).en_US
dc.titleTemporal pressure enhanced topical drug delivery through micropore formationen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.researchNTU Institute for Health Technologiesen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsChemical Equipmenten_US
dc.subject.keywordsDrug Dosageen_US
dc.description.acknowledgementC.X. acknowledges the funding support from Singapore Agency for Science, Technology and Research (A*STAR) Science and Engineering Research Council Additive Manufacturing for Biological Materials (AMBM) program (A18A8b0059) and internal grant from City University of Hong Kong (#9610472). D.L.B. acknowledges the funding support from A*STAR under its Industry Alignment Fund–Pre-Positioning Programme (IAF-PP): (1) Wound Care Innovation for the Tropics Programme, Singapore (WCIT): (H18/01/a0/0I9) and (H17/01/a0/0C9); (2) The Skin Research Institute of Singapore, Phase 2: SRIS@Novena (“IAF-PP SRIS2 Grant”, H17/01/a0/004). X.W. acknowledges the funding support from the National Medical Research Council Singapore Large Collaborative Grant DYNAMO (NMRC/OFLCG/001/2017); and National Medical Research Council Singapore Large Collaborative Grant TAAP (NMRC/OFLCG/004/2018).en_US
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