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Title: Temporal pressure enhanced topical drug delivery through micropore formation
Authors: Lio, Daniel Chin Shiuan
Chia, Ruining
Kwek, Milton Sheng Yi
Wiraja, Christian
Madden, Leigh Edward
Chang, Hao
S. Mohideen Abdul Khadir
Wang, Xiaomeng
Becker, David Lawrence
Xu, Chenjie
Keywords: Science::Medicine
Issue Date: 2020
Source: Lio, D. C. S., Chia, R., Kwek, M. S. Y., Wiraja, C., Madden, L. E., Chang, H., . . . Xu, C. (2020). Temporal pressure enhanced topical drug delivery through micropore formation. Science Advances, 6(22), eaaz6919-. doi:10.1126/sciadv.aaz6919
Project: A18A8b0059
Journal: Science Advances
Abstract: Transdermal drug delivery uses chemical, physical, or biochemical enhancers to cross the skin barrier. However, existing platforms require high doses of chemical enhancers or sophisticated equipment, use fragile biomolecules, or are limited to a certain type of drug. Here, we report an innovative methodology based on temporal pressure to enhance the penetration of all kinds of drugs, from small molecules to proteins and nanoparticles (up to 500 nm). The creation of micropores (~3 μm2) on the epidermal layer through a temporal pressure treatment results in the elevated expression of gap junctions, and reduced expression of occludin tight junctions. A 1 min treatment of 0.28-MPa allows nanoparticles (up to 500 nm) and macromolecules (up to 20 kDa) to reach a depth of 430-μm into the dermal layer. Using, as an example, the delivery of insulin through topical application after the pressure treatment yields up to 80% drop in blood glucose in diabetic mice.
ISSN: 2375-2548
DOI: 10.1126/sciadv.aaz6919
Schools: School of Chemical and Biomedical Engineering 
Interdisciplinary Graduate School (IGS) 
Lee Kong Chian School of Medicine (LKCMedicine) 
Research Centres: NTU Institute for Health Technologies 
Rights: © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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