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Title: Linker-mediated self-assembly of mobile DNA-coated colloids
Authors: Xia, Xiuyang
Hu, Hao
Ciamarra, Massimo Pica
Ni, Ran
Keywords: Engineering::Bioengineering
Issue Date: 2020
Source: Xia, X., Hu, H., Ciamarra, M. P., & Ni, R. (2020). Linker-mediated self-assembly of mobile DNA-coated colloids. Science Advances, 6(21), eaaz6921-. doi:10.1126/sciadv.aaz6921
Project: MOE2017-T2-1-066
Journal: Science Advances
Abstract: Developing construction methods of materials tailored for given applications with absolute control over building block placement poses an immense challenge. DNA-coated colloids offer the possibility of realising programmable self-assembly, which, in principle, can assemble almost any structure in equilibrium, but remains challenging experimentally. Here, we propose an innovative system of linker-mediated mobile DNA-coated colloids (mDNACCs), in which mDNACCs are bridged by the free DNA linkers in solution, whose two single-stranded DNA tails can bind with specific single-stranded DNA receptors of complementary sequence coated on colloids. We formulate a mean-field theory efficiently calculating the effective interaction between mDNACCs, where the entropy of DNA linkers plays a nontrivial role. Particularly, when the binding between free DNA linkers in solution and the corresponding receptors on mDNACCs is strong, the linker-mediated colloidal interaction is determined by the linker entropy depending on the linker concentration.
ISSN: 2375-2548
DOI: 10.1126/sciadv.aaz6921
Rights: © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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