Please use this identifier to cite or link to this item:
Title: MTH1 inhibitor amplifies the lethality of reactive oxygen species to tumor in photodynamic therapy
Authors: Zhao, Lingzhi
Li, Junyao
Su, Yaoquan
Yang, Liqiang
Chen, Liu
Qiang, Lei
Wang, Yajing
Xiang, Huijing
Tham, Phoebe Huijun
Peng, Juanjuan
Zhao, Yanli
Keywords: Science::Medicine
Issue Date: 2020
Source: Zhao, L., Li, J., Su, Y., Yang, L., Chen, L., Qiang, L., . . . Zhao, Y. (2020). MTH1 inhibitor amplifies the lethality of reactive oxygen species to tumor in photodynamic therapy. Science Advances, 6(10), eaaz0575-. doi:10.1126/sciadv.aaz0575
Project: NRF-NRFI2018-03
Journal: Science Advances
Abstract: Although photodynamic therapy (PDT) has been clinically applied tumor hypoxia still greatly restricts the performance of this oxygen-dependent oncological treatment. The delivery of oxygen donors to tumor may produce excessive reactive oxygen species (ROS) and damage the peripheral tissues. Herein, we developed a strategy to solve the hypoxia issue by enhancing the lethality of ROS. Before PDT, the ROS-defensing system of the cancer cells was obstructed by an inhibitor to MTH1, which is a key for the remediation of ROS-caused DNA damage. As a result, both nuclei and mitochondrial DNA damages were increased, remarkably promoting cellular apoptosis. The therapeutic results demonstrated that the performance of PDT can be improved by the MTH1 inhibitor, leading to efficient cancer cell killing effect in the hypoxic tumor. This strategy makes better use of the limited oxygen, holding the promise to achieve satisfactory therapeutic effect by PDT without generating redundant cytotoxic ROS.
ISSN: 2375-2548
DOI: 10.1126/sciadv.aaz0575
Rights: © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

Files in This Item:
File Description SizeFormat 
Science Journals — AAAS - eaaz0575.full.pdf5.67 MBAdobe PDFView/Open

Citations 10

Updated on Jan 28, 2023

Web of ScienceTM
Citations 10

Updated on Jan 29, 2023

Page view(s)

Updated on Jan 31, 2023

Download(s) 50

Updated on Jan 31, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.